ReviewKorean journal of pediatrics2014
Iron deficiency increases blood concentrations of neurotoxic metals in children.
Review in Korean journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Major heavy metals and human gut microbiota composition: a systematic review with nutritional approach.Journal of health, population, and nutrition · 2025Pooled it
- Blood lead concentrations in children with iron deficiency anemia: a systematic review and meta-analysis.Environmental science and pollution research international · 2022Pooled it
- Combined Manganese-Iron Exposure Reduced Oxidative Stress is Associated with the NRF2/NQO1 Pathway in Astrocytic C8-D1A Cells.Biological trace element research · 2026Article
- Metal(oid) profiling of the common site of osteoporotic fractures with bone microarchitecture correlation analysis: a comparative study of hip fracture patients and healthy individuals.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- Lead encephalopathy presenting as status epilepticus: a case report.BMC pediatrics · 2024Article
- Cadmium Induces Kidney Iron Deficiency and Chronic Kidney Injury by Interfering with the Iron Metabolism in Rats.International journal of molecular sciences · 2024Article
- Vitamin D and Toxic Metals in Pregnancy - a Biological Perspective.Current epidemiology reports · 2024Review
- Iron- and protein rich diets may boost hemoglobin levels among informal electronic waste recyclers exposed to metals at Agbogbloshie, Ghana.Hygiene and environmental health advances · 2023Article
- Early life manganese exposure and reported attention-related behaviors in Italian adolescents.Environmental epidemiology (Philadelphia, Pa.) · 2023Article
- Heavy Metals and Human Health: Possible Exposure Pathways and the Competition for Protein Binding Sites.Molecules (Basel, Switzerland) · 2021Review
- Blood Lead Levels in Opium-Poisoned Children: One Cross-Sectional Study in Iran.Addiction & health · 2020Article
- Article
- Metal bashing: iron deficiency and manganese overexposure impact on peripheral nerves.Journal of toxicology and environmental health. Part A · 2019Article
- Trace element and vitamin concentrations in paediatric dialysis patients.Pediatric nephrology (Berlin, Germany) · 2018Article
- Low-Level Toxic Metal Exposure in Healthy Weaning-Age Infants: Association with Growth, Dietary Intake, and Iron Deficiency.International journal of environmental research and public health · 2017Article
- Redox dynamics of manganese as a mitochondrial life-death switch.Biochemical and biophysical research communications · 2017Review
- Associations between metals in residential environmental media and exposure biomarkers over time in infants living near a mining-impacted site.Journal of exposure science & environmental epidemiology · 2016Article
- Manganese in teeth and neurodevelopment in young Mexican-American children.Environmental research · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iron deficiency affects approximately one-third of the world's population, occurring most frequently in children aged 6 months to 3 years. Mechanisms of iron absorption are similar to those of other divalent metals, particularly manganese, lead, and cadmium, and a diet deficient in iron can lead to excess absorption of manganese, lead, and cadmium. Iron deficiency may lead to cognitive impairments resulting from the deficiency itself or from increased metal concentrations caused by the deficiency. Iron deficiency combined with increased manganese or lead concentrations may further affect neurodevelopment. We recently showed that blood manganese and lead concentrations are elevated among iron-deficient infants. Increased blood manganese and lead levels are likely associated with prolonged breast-feeding, which is also a risk factor for iron deficiency. Thus, babies who are breast-fed for prolonged periods should be given plain, iron-fortified cereals or other good sources of dietary iron.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.