ReviewJournal of leukocyte biology2014
Unraveling the complexity of lipid body organelles in human eosinophils.
Review in Journal of leukocyte biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Theory of Lipid Metabolism Disorders in Rhinitis and Asthma (Lipid Droplets).Cell biochemistry and biophysics · 2025Review
- Article
- Eosinophils in Colorectal Cancer: Emerging Insights into Anti-Tumoral Mechanisms and Clinical Implications.International journal of molecular sciences · 2024Review
- Identification of inflammatory markers in eosinophilic cells of the immune system: fluorescence, Raman and CARS imaging can recognize markers but differently.Cellular and molecular life sciences : CMLS · 2021Article
- Lipid Droplets, Phospholipase ABiomedicines · 2021Review
- Emerging Evidence for Pleiotropism of Eosinophils.International journal of molecular sciences · 2021Review
- Regulation of eosinophil functions by autophagy.Seminars in immunopathology · 2021Review
- A new dawn for eosinophils in the tumour microenvironment.Nature reviews. Cancer · 2020Review
- Article
- Approach to Patients with Eosinophilia.The Medical clinics of North America · 2020Review
- Eosinophils in the gastrointestinal tract and their role in the pathogenesis of major colorectal disorders.World journal of gastroenterology · 2019Review
- Eosinophils: Nemeses of Pulmonary Pathogens?Current allergy and asthma reports · 2019Review
- Reuse of public, genome-wide, murine eosinophil expression data for hypotheses development.Journal of leukocyte biology · 2018Article
- Cysteinyl Leukotrienes in Eosinophil Biology: Functional Roles and Therapeutic Perspectives in Eosinophilic Disorders.Frontiers in medicine · 2017Review
- Liver-specific loss of Perilipin 2 alleviates diet-induced hepatic steatosis, inflammation, and fibrosis.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
- Interleukin-5 pathway inhibition in the treatment of eosinophilic respiratory disorders: evidence and unmet needs.Current opinion in allergy and clinical immunology · 2016Review
- Microdomains, Inflammation, and Atherosclerosis.Circulation research · 2016Review
- Lipid droplets in leukocytes: Organelles linked to inflammatory responses.Experimental cell research · 2016Review
- Host Lipid Bodies as Platforms for Intracellular Survival of Protozoan Parasites.Frontiers in immunology · 2016Review
- Lipid Body Organelles within the Parasite Trypanosoma cruzi: A Role for Intracellular Arachidonic Acid Metabolism.PloS one · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Lipid-rich organelles are common in many cell types. In cells, such as adipocytes, these organelles are termed LDs, whereas in other cells, such as leukocytes, they are called LBs. The study of leukocyte LBs has attracted attention as a result of their association with human diseases. In leukocytes, such as eosinophils, LB accumulation has been documented extensively during inflammatory conditions. In these cells, LBs are linked to the regulation of immune responses by compartmentalization of several proteins and lipids involved in the control and biosynthesis of inflammatory mediators (eicosanoids). However, it has been unclear how diverse proteins, including membrane-associated enzymes involved in eicosanoid formation, incorporate into LBs, especially if the internal content of LBs is assumed to consist solely of stores of neutral lipids, as present within adipocyte LDs. Studies of the formation, function, and ultrastructure of LBs in eosinophils have been providing insights pertinent to LBs in other leukocytes. Here, we review current knowledge of the composition and function of leukocyte LBs as provided by studies of human eosinophil LBs, including recognitions of the internal architecture of eosinophil LBs based on 3D electron tomographic analyses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.