ArticleSchizophrenia bulletin2015
Schizophrenia and autism as contrasting minds: neural evidence for the hypo-hyper-intentionality hypothesis.
Article in Schizophrenia bulletin, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 156 citations in OpenAlex.
- Autism spectrum disorder and schizophrenia: An updated conceptual review.Autism research : official journal of the International Society for Autism Research · 2022Pooled it
- Abnormal Brain Activation During Theory of Mind Tasks in Schizophrenia: A Meta-Analysis.Schizophrenia bulletin · 2017Pooled it
- Transcranial Direct Current Stimulation of the Temporoparietal Junction in Autism Spectrum Disorder: Results of a Phase-IIa Randomized, Double-Blind, Sham-Controlled Feasibility Study.Autism research : official journal of the International Society for Autism Research · 2025Trial
- Integrating EEG and fMRI in naturalistic paradigms: Advances in understanding mental disorders-a decade study in review (2014-2024).Dialogues in clinical neuroscience · 2026Review
- The Network Model of Mentalization, Social Vulnerability, and the Self in Autism: A Comparison With Neurotypical Adults.Autism research : official journal of the International Society for Autism Research · 2026Article
- Triple-Network Functional Connectivity in Adolescents With Autism Spectrum Disorder Compared to Early-Onset Psychosis.Autism research : official journal of the International Society for Autism Research · 2026Article
- Transdiagnostic Profiles of BOLD Signal Variability in Autism and Schizophrenia Spectrum Disorders: Associations With Cognition and Functioning.Human brain mapping · 2026Article
- Comparative Analysis of Social Cognitive and Neurocognitive Performance Across Autism and Schizophrenia Spectrum Disorders.Schizophrenia bulletin · 2026Article
- Clinical implications of autistic features in the psychosis spectrum: a cross-sectional study using path analysis.BMC psychiatry · 2025Article
- Identifying overlapping and distinctive traits of autism and schizophrenia using machine learning classification.Cognitive neuropsychiatry · 2025Article
- Altered neural response to social awkwardness in schizophrenia spectrum disorders.Social cognitive and affective neuroscience · 2024Article
- Associations between antagonistic SNPs for neuropsychiatric disorders and human brain structure.Translational psychiatry · 2024Article
- Task-based functional neural correlates of social cognition across autism and schizophrenia spectrum disorders.Molecular autism · 2024Article
- Connectivity differences between inferior frontal gyrus and mentalizing network in autism as compared to developmental coordination disorder and non-autistic youth.Cortex; a journal devoted to the study of the nervous system and behavior · 2023Article
- A neuro-computational social learning framework to facilitate transdiagnostic classification and treatment across psychiatric disorders.Neuroscience and biobehavioral reviews · 2023Review
- Intention Attribution in Children and Adolescents with Autism Spectrum Disorder: An EEG Study.Journal of autism and developmental disorders · 2023Article
- Neural responses to biological motion distinguish autistic and schizotypal traits.Social cognitive and affective neuroscience · 2023Article
- Towards a comprehensive approach to mentalization-based treatment for children with autism: integrating attachment, neurosciences, and mentalizing.Frontiers in psychiatry · 2023Article
- Atypical Dynamic Functional Network Connectivity State Engagement during Social-Emotional Processing in Schizophrenia and Autism.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Qualitative Differences in Attribution of Mental States to Other People in Autism and Schizophrenia: What are the Tools for Differential Diagnosis?Journal of autism and developmental disorders · 2022Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Both schizophrenia (SCZ) and autism spectrum disorder (ASD) are characterized by mentalizing problems and associated neural dysfunction of the social brain. However, the deficits in mental state attribution are somehow opposed: Whereas patients with SCZ tend to over-attribute intentions to agents and physical events ("hyper-intentionality"), patients with autism treat people as devoid of intentions ("hypo-intentionality"). Here we aimed to investigate whether this hypo-hyper-intentionality hypothesis can be supported by neural evidence during a mentalizing task. Using functional magnetic resonance imaging (fMRI), we investigated the neural responses and functional connectivity during reading others intention. Scanning was performed in 23 individuals with ASD, 18 with paranoid SCZ and 23 gender and IQ matched control subjects. Both clinical groups showed reduced brain activation compared to controls for the contrast intentional vs physical information processing in left posterior superior temporal sulcus (pSTS) and ventral medial prefrontal cortex (vMPFC) for SCZ, and right pSTS in ASD. As predicted, these effects were caused in a group specific way: Relative increased activation for physical information processing in SCZ that was also correlated with positive PANNS score and relative decreased activation for intentional information processing in ASD. Additionally, we could demonstrate opposed connectivity patterns between the right pSTS and vMPFC in the clinical groups, ie, increased for SCZ, decreased for ASD. These findings represent opposed neural signatures in key regions of the social brain as predicted by the hyper-hypo-intentionality hypothesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.