ArticleParticle and fibre toxicology2014
Mechanisms of nanosized titanium dioxide-induced testicular oxidative stress and apoptosis in male mice.
Article in Particle and fibre toxicology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Impact of Nanoparticles on Male Fertility: What Do We Really Know? A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Higher Sensitivity of Rat Testes to Nano Nickel than Micro Nickel Particles: A Toxicological Evaluation.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Article
- Impact of chitosan administration on titanium dioxide nanoparticles induced testicular dysfunction.Scientific reports · 2022Article
- miR-146b-5p Plays a Critical Role in the Regulation of Autophagy in ∆perBioMed research international · 2020Article
- Hazardous Effects of Titanium Dioxide Nanoparticles in Ecosystem.Bioinorganic chemistry and applications · 2017Review
- Retraction Note: Mechanisms of nanosized titanium dioxide-induced testicular oxidative stress and apoptosis in male mice.Particle and fibre toxicology · 2015Article
- Effects of silver nanoparticles on neonatal testis development in mice.International journal of nanomedicine · 2015Article
Corrections and comments
- Retraction · 2015-07-14Duplication of/in Image · Error in Analyses · Error in Methods · Investigation by Company/Institution · Investigation by Journal/Publisher · Objections by Third Party ·
- Retracted
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDue to the increased application of titanium dioxide nanoparticles (TiO₂ NPs) in the food industry and daily life, their potential toxic effects in humans and animals have been investigated. However, very few studies have focused on testicular oxidative stress and/or apoptosis.
methodsIn order to understand the possible molecular mechanisms of testicular lesions following exposure to TiO₂ NPs, male mice were exposed to 2.5, 5, or 10 mg/kg body weight TiO₂ NPs for 90 consecutive days. Testicular oxidative stress and apoptosis were then evaluated, and the testicular mRNA expression of several genes and their proteins involved in oxidative stress and/or apoptosis was investigated.
resultsTiO₂ NPs entered Sertoli cells and caused severe testicular oxidative damage and/or apoptosis, accompanied by excessive production of reactive oxygen species and peroxidation of lipids, proteins and DNA as well as a significant reduction in antioxidant capacity. Furthermore, exposure to TiO₂ NPs resulted in the up-regulation of caspase-3, Nrbp2, and cytochrome c expression, and caused down-regulation of SOD, CAT, GPx, GST, GR, Cyp1b1, Car3, Bcl-2, Acaa2, and Axud1 expression in mouse testis.
conclusionsTiO₂ NPs entered Sertoli cells via the blood-testis barrier and were deposited in mouse seminiferous cord and/or Sertoli cells, causing oxidative damage and apoptosis.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.