Evidence map›Paper›PMID 25209713›Full record

ArticleScientific reports2014

Changes of the human gut microbiome induced by a fermented milk product.

Patrick Veiga, Nicolas Pons, Anurag Agrawal, Raish Oozeer, Denis Guyonnet, Rémi Brazeilles, Jean-Michel Faurie, Johan E T van Hylckama Vlieg, Lesley A Houghton, Peter J Whorwell and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed, 6 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

110 citing papers in PubMed, 6 syntheses or guidelines pooled it, 250 citations in OpenAlex.

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50 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Patrick VeigaDanone Nutricia Research, Palaiseau, France.
Nicolas PonsINRA, Metagenopolis, Jouy-en-Josas, France.
Anurag AgrawalNeurogastroenterology Unit, University of Manchester, Manchester, United Kingdom.
Raish OozeerDanone Nutricia Research, Palaiseau, France.
Denis GuyonnetDanone Nutricia Research, Palaiseau, France.
Rémi BrazeillesC2R, Paris, France.
Jean-Michel FaurieDanone Nutricia Research, Palaiseau, France.
Johan E T van Hylckama VliegDanone Nutricia Research, Palaiseau, France.
Lesley A Houghton1] Centre for Gastrointestinal Sciences, University of Manchester, University Hospital of South Manchester, Manchester, United Kingdom [2] Division of Gastroenterology and Hepatology, Mayo Clinic, Florida, USA.
Peter J WhorwellCentre for Gastrointestinal Sciences, University of Manchester, University Hospital of South Manchester, Manchester, United Kingdom.
S Dusko Ehrlich1] INRA, Metagenopolis, Jouy-en-Josas, France [2] Centre for Human Microbiome Interactions, King's College London, London, United Kingdom.
Sean P KennedyINRA, Metagenopolis, Jouy-en-Josas, France.
Danone (France) · FRUniversity of Manchester · GBCentre de recherche et de restauration des musées de France · FRKing's College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut microbiota (GM) consists of resident commensals and transient microbes conveyed by the diet but little is known about the role of the latter on GM homeostasis. Here we show, by a conjunction of quantitative metagenomics, in silico genome reconstruction and metabolic modeling, that consumption of a fermented milk product containing dairy starters and Bifidobacterium animalis potentiates colonic short chain fatty acids production and decreases abundance of a pathobiont Bilophila wadsworthia compared to a milk product in subjects with irritable bowel syndrome (IBS, n = 28). The GM changes parallel improvement of IBS state, suggesting a role of the fermented milk bacteria in gut homeostasis. Our data challenge the view that microbes ingested with food have little impact on the human GM functioning and rather provide support for beneficial health effects.

Indexed as

Cultured Milk ProductsProbioticsBifidobacteriumBilophilaButyratesDietFecesFood MicrobiologyHumansIrritable Bowel SyndromeLactobacillus delbrueckiiLactococcus lactisMicrobiotaRNA, Ribosomal, 16SStomachStreptococcus thermophilusButyratesRNA, Ribosomal, 16S

Identifiers

PMID25209713
PMCPMC4160712
OpenAlexW1976125819

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.