ArticleCerebral cortex (New York, N.Y. : 1991)2015
Disruption of Visc-2, a Brain-Expressed Conserved Long Noncoding RNA, Does Not Elicit an Overt Anatomical or Behavioral Phenotype.
Article in Cerebral cortex (New York, N.Y. : 1991), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Involvement of the long intergenic non-coding RNA LINC00461 in schizophrenia.BMC psychiatry · 2022Pooled it
- Genome-wide meta-analysis identifies novel loci associated with age-related macular degeneration.Journal of human genetics · 2020Pooled it
- Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder.Nature genetics · 2019Pooled it
- Post-operative atrial fibrillation examined using whole-genome RNA sequencing in human left atrial tissue.BMC medical genomics · 2017Trial
- Phenotypic and genetic characteristics of retinal vascular parameters and their association with diseases.Nature communications · 2024Article
- Sex-specific role for the long noncoding RNA Pnky in mouse behavior.Nature communications · 2024Article
- Sex-specific role for the long noncoding RNAbioRxiv : the preprint server for biology · 2023Article
- Cell-specific cis-regulatory elements and mechanisms of non-coding genetic disease in human retina and retinal organoids.Developmental cell · 2022Article
- Genetic evidence suggests posttraumatic stress disorder as a subtype of major depressive disorder.The Journal of clinical investigation · 2022Article
- Behavioural Characterisation ofCells · 2021Article
- Mutant non-coding RNA resource in mouse embryonic stem cells.Disease models & mechanisms · 2021Article
- Reverse-genetics studies of lncRNAs-what we have learnt and paths forward.Genome biology · 2020Review
- Identifying common genome-wide risk genes for major psychiatric traits.Human genetics · 2020Article
- Modulating the expression of long non-coding RNAs for functional studies.EMBO reports · 2018Review
- LINC00461, a long non-coding RNA, is important for the proliferation and migration of glioma cells.Oncotarget · 2017Article
- Oncogenic effects of evolutionarily conserved noncoding RNA ECONEXIN on gliomagenesis.Oncogene · 2017Article
- Understanding the Role of lncRNAs in Nervous System Development.Advances in experimental medicine and biology · 2017Review
- Long noncoding RNAs: Central to nervous system development.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2016Review
- Investigating long noncoding RNAs using animal models.The Journal of clinical investigation · 2016Review
- Epigenomic elements analyses for promoters identify ESRRG as a new susceptibility gene for obesity-related traits.International journal of obesity (2005) · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
Although long noncoding RNAs (lncRNAs) are proposed to play essential roles in mammalian neurodevelopment, we know little of their functions from their disruption in vivo. Combining evidence for evolutionary constraint and conserved expression data, we previously identified candidate lncRNAs that might play important and conserved roles in brain function. Here, we demonstrate that the sequence and neuronal transcription of lncRNAs transcribed from the previously uncharacterized Visc locus are conserved across diverse mammals. Consequently, one of these lncRNAs, Visc-2, was selected for targeted deletion in the mouse, and knockout animals were subjected to an extremely detailed anatomical and behavioral characterization. Despite a neurodevelopmental expression pattern of Visc-2 that is highly localized to the cortex and sites of neurogenesis, anomalies in neither cytoarchitecture nor neuroproliferation were identified in knockout mice. In addition, no abnormal motor, sensory, anxiety, or cognitive behavioral phenotypes were observed. These results are important because they contribute to a growing body of evidence that lncRNA loci contribute on average far less to brain and biological functions than protein-coding loci. A high-throughput knockout program focussing on lncRNAs, similar to that currently underway for protein-coding genes, will be required to establish the distribution of their organismal functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.