Evidence map›Paper›PMID 25209321›Full record

ArticleNano letters2014

Reversible positioning of single molecules inside zero-mode waveguides.

Joseph Larkin, Mathieu Foquet, Stephen W Turner, Jonas Korlach, Meni Wanunu

Abstract read
In one paragraph

Article in Nano letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
  2. Gold Ion Beam Milled Gold Zero-Mode Waveguides.Nanomaterials (Basel, Switzerland) · 2022
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Observing Single-Molecule Dynamics at Millimolar Concentrations.Angewandte Chemie (International ed. in English) · 2017
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Joseph LarkinDepartment of Physics and ‡Department of Chemistry/Chemical Biology, Northeastern University , 110 Forsyth Street, Boston, Massachusetts 02115, United States.
Mathieu Foquet
Stephen W Turner
Jonas Korlach
Meni Wanunu

Funding

Picogram-level DNA sequencing using Nanopores and Zero-Mode WaveguidesR21HG006873 · NHGRI · NORTHEASTERN UNIVERSITY · PI KORLACH, JONAS, WANUNU, MENI · 2012 to 2014
$812k
NHGRI NIH HHS R21 HG006873NHGRI NIH HHS R21-HG006873
6 · The paper itself

Abstract

We have developed a hybrid nanopore/zero-mode waveguide device for single-molecule fluorescence and DNA sequencing applications. The device is a freestanding solid-state membrane with sub-5 nm nanopores that reversibly delivers individual biomolecules to the base of 70 nm diameter waveguides for interrogation. Rapid and reversible molecular loading is achieved by controlling the voltage across the device. Using this device we demonstrate protein and DNA loading with efficiency that is orders of magnitude higher than diffusion-based molecular loading.

Indexed as

DiffusionDNAEquipment DesignFluorescenceModels, MolecularNanoporesNanotechnologyOptical ImagingProteinsSequence Analysis, DNADNAProteinsDNA sequencingnanophotonicssingle moleculeSMRT-sequencingzeptoliter

Identifiers

PMID25209321
PMCPMC4189617

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.