ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Cross-inhibition of NMBR and GRPR signaling maintains normal histaminergic itch transmission.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 66 citations in OpenAlex.
- Exploring the distinct activation mechanisms of neuromedin B receptor through multiple replica molecular dynamics simulations and Markov state modeling.Acta pharmacologica Sinica · 2025Article
- Neuromedin B identified as a therapeutic target for atopic dermatitis: evidence from Mendelian randomization and PCR validation.Frontiers in medicine · 2025Article
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- Kappa opioids inhibit spinal output neurons to suppress itch.Science advances · 2024Article
- Pain and itch coding mechanisms of polymodal sensory neurons.Cell reports · 2023Article
- Identification of a convergent spinal neuron population that encodes itch.bioRxiv : the preprint server for biology · 2023Article
- Descending dopaminergic pathway facilitates itch signal processing via activating spinal GRPREMBO reports · 2023Article
- Function of gastrin-releasing peptide receptors in ocular itch transmission in the mouse trigeminal sensory system.Frontiers in molecular neuroscience · 2023Article
- Characterization of the expression of gastrin-releasing peptide and its receptor in the trigeminal and spinal somatosensory systems of Japanese macaque monkeys: Insight into humans.The Journal of comparative neurology · 2022Article
- Footedness for scratching itchy eyes in rodents.Proceedings. Biological sciences · 2022Article
- Itch-specific neurons in the ventrolateral orbital cortex selectively modulate the itch processing.Science advances · 2022Article
- Molecular and neural basis of pleasant touch sensation.Science (New York, N.Y.) · 2022Article
- Functional roles of neuromedin B and gastrin-releasing peptide in regulating itch and pain in the spinal cord of non-human primates.Biochemical pharmacology · 2022Article
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- A neuropeptide code for itch.Nature reviews. Neuroscience · 2021Review
- Estrogens influence female itch sensitivity via the spinal gastrin-releasing peptide receptor neurons.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
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- The Neurokinin-1 Receptor is Expressed with Gastrin-Releasing Peptide Receptor in Spinal Interneurons and Modulates Itch.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- A spinal neural circuitry for converting touch to itch sensation.Nature communications · 2020Article
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Authors and funding
13 authors at 6 institutions in 4 countries.
Funding
Abstract
We previously showed that gastrin-releasing peptide receptor (GRPR) in the spinal cord is important for mediating nonhistaminergic itch. Neuromedin B receptor (NMBR), the second member of the mammalian bombesin receptor family, is expressed in a largely nonoverlapping pattern with GRPR in the superficial spinal cord, and its role in itch transmission remains unclear. Here, we report that Nmbr knock-out (KO) mice exhibited normal scratching behavior in response to intradermal injection of pruritogens. However, mice lacking both Nmbr and Grpr (DKO mice) showed significant deficits in histaminergic itch. In contrast, the chloroquine (CQ)-evoked scratching behavior of DKO mice is not further reduced compared with Grpr KO mice. These results suggest that NMBR and GRPR could compensate for the loss of each other to maintain normal histamine-evoked itch, whereas GRPR is exclusively required for CQ-evoked scratching behavior. Interestingly, GRPR activity is enhanced in Nmbr KO mice despite the lack of upregulation of Grpr expression; so is NMBR in Grpr KO mice. We found that NMB acts exclusively through NMBR for itch transmission, whereas GRP can signal through both receptors, albeit to NMBR to a much lesser extent. Although NMBR and NMBR(+) neurons are dispensable for histaminergic itch, GRPR(+) neurons are likely to act downstream of NMBR(+) neurons to integrate NMB-NMBR-encoded histaminergic itch information in normal physiological conditions. Together, we define the respective function of NMBR and GRPR in itch transmission, and reveal an unexpected relationship not only between the two receptors but also between the two populations of interneurons in itch signaling.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.