ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Neuromodulators produce distinct activated states in neocortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 68 citations in OpenAlex.
- Catecholamine-Mediated Increases in Gain Enhance the Precision of Cortical Representations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Trial
- The Duality of Astrocyte Neuromodulation: Astrocytes Sense Neuromodulators and Are Neuromodulators.Journal of neurochemistry · 2025Review
- Aperiodic spectral slope tracks the effects of brain state on saliency responses in the human auditory cortex.Scientific reports · 2024Article
- The Locus Coeruleus in Chronic Pain.International journal of molecular sciences · 2024Review
- Article
- A whole new world: embracing the systems-level to understand the indirect impact of pathology in neurodegenerative disorders.Journal of neurology · 2023Review
- Article
- Dexmedetomidine Preserves Activity of Neurons in Primary Somatosensory Cortex Compared to Propofol and Ketamine.Brain sciences · 2022Article
- Structural connections between the noradrenergic and cholinergic system shape the dynamics of functional brain networks.NeuroImage · 2022Article
- Barrel cortex VIP/ChAT interneurons suppress sensory responses in vivo.PLoS biology · 2020Article
- Ceftriaxone modulates the acute corticosterone effects in local field potentials in the primary somatosensory cortex of anesthetized mice.Scientific reports · 2019Article
- Locus coeruleus-norepinephrine modulation of sensory processing and perception: A focused review.Neuroscience and biobehavioral reviews · 2019Review
- Cellular, Synaptic and Network Effects of Acetylcholine in the Neocortex.Frontiers in neural circuits · 2019Review
- Membrane Potential Correlates of Network Decorrelation and Improved SNR by Cholinergic Activation in the Somatosensory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Differential Role of Prefrontal and Parietal Cortices in Controlling Level of Consciousness.Current biology : CB · 2018Article
- Synaptic Release of Acetylcholine Rapidly Suppresses Cortical Activity by Recruiting Muscarinic Receptors in Layer 4.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Time to wake up: Studying neurovascular coupling and brain-wide circuit function in the un-anesthetized animal.NeuroImage · 2017Review
- How neuroscience can inform the study of individual differences in cognitive abilities.Reviews in the neurosciences · 2017Review
- Antiarrhythmics cure brain arrhythmia: The imperativeness of subthalamic ERG KScience advances · 2017Article
- Coupling between spontaneous pupillary fluctuations and brain activity relates to inattentiveness.The European journal of neuroscience · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Neocortical population activity varies between deactivated and activated states marked by the presence and absence of slow oscillations, respectively. Neocortex activation occurs during waking and vigilance and is readily induced in anesthetized animals by stimulating the brainstem reticular formation, basal forebrain, or thalamus. Neuromodulators are thought to be responsible for these changes in cortical activity, but their selective cortical effects (i.e., without actions in other brain areas) on neocortical population activity in vivo are not well defined. We found that selective cholinergic and noradrenergic stimulation of the barrel cortex produces well differentiated activated states in rats. Cholinergic cortical stimulation activates the cortex by abolishing synchronous slow oscillations and shifting firing to a tonic mode, which increases in rate at high doses. This shift causes the sensory thalamus itself to become activated. In contrast, noradrenergic cortical stimulation activates the cortex by abolishing synchronous slow oscillations but suppresses overall cortical firing rate, which deactivates the thalamus. Cortical activation produced by either of these neuromodulators leads to suppressed sensory responses and more focused receptive fields. High-frequency sensory stimuli are best relayed to barrel cortex during cortical cholinergic activation because this also activates the thalamus. Cortical neuromodulation sets different cortical and thalamic states that may serve to control sensory information processing according to behavioral contingencies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.