ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Thalamic δ-subunit containing GABAA receptors promote electrocortical signatures of deep non-REM sleep but do not mediate the effects of etomidate at the thalamus in vivo.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 33 citations in OpenAlex.
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- EEG in Down Syndrome-A Review and Insights into Potential Neural Mechanisms.Brain sciences · 2024Review
- Optical and pharmacological manipulation of hypoglossal motor nucleus identifies differential effects of taltirelin on sleeping tonic motor activity and responsiveness.Scientific reports · 2023Article
- Circuits and components of delta wave regulation.Brain research bulletin · 2022Review
- Translational approaches to influence sleep and arousal.Brain research bulletin · 2022Review
- Mice Lacking GABAFrontiers in pharmacology · 2021Article
- Discovery of a new class of orthosteric antagonists with nanomolar potency at extrasynaptic GABAScientific reports · 2020Article
- Measurement and State-Dependent Modulation of Hypoglossal Motor Excitability and Responsivity In-Vivo.Scientific reports · 2020Article
- Increased Sensitivity of Mice Lacking Extrasynaptic δ-Containing GABAFrontiers in pharmacology · 2020Article
- δ-Subunit Containing GABAScientific reports · 2017Article
- Activation of the Hypoglossal to Tongue Musculature Motor Pathway by Remote Control.Scientific reports · 2017Article
- TASK Channels on Basal Forebrain Cholinergic Neurons Modulate Electrocortical Signatures of Arousal by Histamine.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- A thalamic origin to the electrocortical patterns associated with transitions into anesthetic-induced loss-of-consciousness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
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3 authors at 1 institution in 1 country.
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Abstract
Extrasynaptic δ-subunits containing GABAA receptors (δGABAARs) are sensitive targets for several commonly used hypnotic agents and mediate tonic neuronal inhibition. δGABAARs are highly expressed within the thalamus and their activation promotes a switch from tonic to burst firing in vitro. Here we test two hypotheses in vivo. (1) Activation of thalamic δGABAARs will elicit electrocortical signatures consistent with widespread thalamocortical burst firing such as increased delta oscillations (1-4 Hz) and reciprocal changes in spindle-like oscillations (7-14 Hz). (2) These signatures will be recapitulated by the general anesthetic etomidate, if the electrocortical effects of etomidate at the thalamus are mediated by δGABAARs. Microperfusion of the δGABAAR-preferring agonist 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol (THIP; 10 and 50 μM) into the ventrobasal complex produced significant effects on electrocortical activity in wild-type mice, but not in mice lacking δGABAARs (Gabrd(-/-)), i.e., the effects with THIP were dependent on δGABAARs. THIP (1) increased 1-4 Hz power in wakefulness and nonrapid-eye movement (NREM) sleep; (2) reduced spindle-like oscillations in NREM sleep; and (3) increased the speed of stable transitions into NREM sleep, indicating effects on state-space dynamics. In contrast, microperfusion of etomidate (10 and 30 μM) into the ventrobasal complex produced effects on electrocortical activity that were independent of δGABAARs, i.e., effects occurred in wild-type and Gabrd(-/-) mice. Etomidate (1) decreased 1-4 Hz power, increased 8-12 Hz, and/or 12-30 Hz power in all sleep-wake states; (2) increased spindle-like oscillations; and (3) increased REM sleep expression. These results indicate that thalamic δGABAARs promote electrocortical signatures of deep NREM sleep, but do not mediate the effects of etomidate at the thalamus in vivo.
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