ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Olfactory receptor patterning in a higher primate.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 82 citations in OpenAlex.
- Role of Glial Trace Amine Associated Receptor 1 (TAAR1) and Microbiota in Schizophrenia.Neurochemical research · 2025Review
- Foxg1 and Retinoic Acid Signaling Regulate Zonal Patterning in the Developing Olfactory Epithelium.Development, growth & differentiation · 2025Article
- Deorphanization of Olfactory Trace Amine-Associated Receptors.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Structures and functions of the normal and injured human olfactory epithelium.Frontiers in neural circuits · 2024Review
- Olfactory Function and Olfactory Disorders.Laryngo- rhino- otologie · 2023Article
- Comparative Aspects of Ricin Toxicity by Inhalation.Toxins · 2023Review
- Ancient and Nonuniform Loss of Olfactory Receptor Expression Renders the Shark Nose a De Facto Vomeronasal Organ.Molecular biology and evolution · 2023Article
- Genome-Wide RNA Tomography in the Mouse Whole Olfactory Mucosa.Methods in molecular biology (Clifton, N.J.) · 2023Article
- MRI tractography reveals the human olfactory nerve map connecting the olfactory epithelium and olfactory bulb.Communications biology · 2022Article
- Spatial organization of olfactory receptor gene choice in the complete V1R-related ORA family of zebrafish.Scientific reports · 2022Article
- Evaluation of Approach to a Conspecific and Blood Biochemical Parameters in TAAR1 Knockout Mice.Brain sciences · 2022Article
- A 3D transcriptomics atlas of the mouse nose sheds light on the anatomical logic of smell.Cell reports · 2022Article
- Pattern of TAAR5 Expression in the Human Brain Based on Transcriptome Datasets Analysis.International journal of molecular sciences · 2021Article
- Cadaverine and Spermine Elicit CaJournal of molecular neuroscience : MN · 2021Article
- Odor coding in the mammalian olfactory epithelium.Cell and tissue research · 2021Review
- Olfactory signaling via trace amine-associated receptors.Cell and tissue research · 2021Review
- TAAR Agonists.Cellular and molecular neurobiology · 2020Review
- A transcriptomic atlas of mammalian olfactory mucosae reveals an evolutionary influence on food odor detection in humans.Science advances · 2019Article
- Sense of Smell: Structural, Functional, Mechanistic Advancements and Challenges in Human Olfactory Research.Current neuropharmacology · 2019Article
- A Near-Complete Spatial Map of Olfactory Receptors in the Mouse Main Olfactory Epithelium.Chemical senses · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The mammalian olfactory system detects a plethora of environmental chemicals that are perceived as odors or stimulate instinctive behaviors. Studies using odorant receptor (OR) genes have provided insight into the molecular and organizational strategies underlying olfaction in mice. One important unanswered question, however, is whether these strategies are conserved in primates. To explore this question, we examined the macaque, a higher primate phylogenetically close to humans. Here we report that the organization of sensory inputs in the macaque nose resembles that in mouse in some respects, but not others. As in mouse, neurons with different ORs are interspersed in the macaque nose, and there are spatial zones that differ in their complement of ORs and extend axons to different domains in the olfactory bulb of the brain. However, whereas the mouse has multiple discrete band-like zones, the macaque appears to have only two broad zones. It is unclear whether the organization of OR inputs in a rodent/primate common ancestor degenerated in primates or, alternatively became more sophisticated in rodents. The mouse nose has an additional small family of chemosensory receptors, called trace amine-associated receptors (TAARs), which may detect social cues. Here we find that TAARs are also expressed in the macaque nose, suggesting that TAARs may also play a role in human olfactory perception. We further find that one human TAAR responds to rotten fish, suggesting a possible role as a sentinel to discourage ingestion of food harboring pathogenic microorganisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.