ReviewProtein science : a publication of the Protein Society2014
New roles for old modifications: emerging roles of N-terminal post-translational modifications in development and disease.
Review in Protein science : a publication of the Protein Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Multicomponent Oxidative Nitrile Thiazolidination Reaction for Selective Modification of N-terminal Dimethylation Posttranslational Modification.Journal of the American Chemical Society · 2023Article
- Impact of Protein NLife (Basel, Switzerland) · 2023Review
- Design and characterization of PROTAC degraders specific to protein N-terminal methyltransferase 1.European journal of medicinal chemistry · 2022Article
- Methyltransferases: Functions and Applications.Chembiochem : a European journal of chemical biology · 2022Review
- Review
- Past, present, and perspectives of protein N-terminal methylation.Current opinion in chemical biology · 2021Review
- Modulation of N-terminal methyltransferase 1 by an NBiochemical and biophysical research communications · 2021Article
- Article
- Fine Tuning: Effects of Post-Translational Modification on Hsp70 Chaperones.International journal of molecular sciences · 2019Review
- Natural Products Containing 'Rare' Organophosphorus Functional Groups.Molecules (Basel, Switzerland) · 2019Review
- N-terminal acetylation and methylation differentially affect the function of MYL9.The Biochemical journal · 2018Article
- The ribosome: A hot spot for the identification of new types of protein methyltransferases.The Journal of biological chemistry · 2018Article
- Depletion of histone N-terminal-acetyltransferase Naa40 induces p53-independent apoptosis in colorectal cancer cells via the mitochondrial pathway.Apoptosis : an international journal on programmed cell death · 2016Article
- Structural basis for substrate recognition by the human N-terminal methyltransferase 1.Genes & development · 2015Article
- N-terminal modifications of cellular proteins: The enzymes involved, their substrate specificities and biological effects.Proteomics · 2015Review
- NRMT1 knockout mice exhibit phenotypes associated with impaired DNA repair and premature aging.Mechanisms of ageing and development · 2015Article
- Nonsynonymous Single-Nucleotide Variations on Some Posttranslational Modifications of Human Proteins and the Association with Diseases.Computational and mathematical methods in medicine · 2015Article
- New OprM structure highlighting the nature of the N-terminal anchor.Frontiers in microbiology · 2015Article
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Authors and funding
2 authors.
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Abstract
The importance of internal post-translational modification (PTM) in protein signaling and function has long been known and appreciated. However, the significance of the same PTMs on the alpha amino group of N-terminal amino acids has been comparatively understudied. Historically considered static regulators of protein stability, additional functional roles for N-terminal PTMs are now beginning to be elucidated. New findings show that N-terminal methylation, along with N-terminal acetylation, is an important regulatory modification with significant roles in development and disease progression. There are also emerging studies on the enzymology and functional roles of N-terminal ubiquitylation and N-terminal propionylation. Here, will discuss the recent advances in the functional studies of N-terminal PTMs, recount the new N-terminal PTMs being identified, and briefly examine the possibility of dynamic N-terminal PTM exchange.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.