Evidence map›Paper›PMID 25209031›Full record

SynthesisEuropean journal of nutrition2014

Body mass index and the risk of gout: a systematic review and dose-response meta-analysis of prospective studies.

Dagfinn Aune, Teresa Norat, Lars J Vatten

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European journal of nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 10 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 10 syntheses or guidelines pooled it, 89 citations in OpenAlex.

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  5. Obesity in adults: a clinical practice guideline.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2020 · on this map
    Guideline
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  13. [A study of burden of gout disease in adults attributable to high body mass index and impaired kidney function in China from 1990 to 2023].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Dagfinn AuneDepartment of Public Health, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway, d.aune@imperial.ac.uk.
Teresa Norat
Lars J Vatten
Norwegian University of Science and Technology · NOSt Mary's Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeGreater body fatness has been associated with increased risk of gout in several studies; however, the strength of the association has differed between studies, and it is not clear whether the association differs by gender. We conducted a systematic review and meta-analysis of prospective studies to clarify the association between adiposity and risk of gout.

methodsPubMed and Embase were searched up to August 30, 2013. Summary relative risks (RRs) were calculated using a random effects model.

resultsTen prospective studies of body mass index (BMI) and gout risk with 27,944 cases and 215,739 participants were included (median follow-up 10.5 years). The summary RR for a 5 unit increment was 1.55 [95% confidence interval (95% CI) 1.44-1.66, I(2) = 67%] for all studies combined. The heterogeneity was explained by one study, which appeared to be an outlier. The summary RR per 5 BMI units was 1.62 (95% CI 1.33-1.98, I(2) = 79%) for men and 1.49 (95% CI 1.32-1.68, I(2) = 30%) for women, p(heterogeneity) = 0.72. The relative risks were 1.78, 2.67, 3.62, and 4.64 for persons with BMI 25, 30, 35, and 40 compared with persons with a BMI of 20. BMI in young adulthood, waist-to-hip ratio, and weight gain from age 21-25 to midlife were also associated with increased risk, but few studies were included in these analyses.

conclusionsGreater body mass index increases risk of gout. Further studies are needed on adiposity throughout the life course, waist-to-hip ratio, and weight changes in relation to gout as there were few studies that had published on these exposures.

Indexed as

Body Mass IndexAdiposityDatabases, FactualFemaleGoutHumansMaleObesityPrevalenceRisk FactorsSensitivity and SpecificityWaist-Hip RatioWeight Gain

Identifiers

PMID25209031
OpenAlexW2105840859

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.