ArticleThe journal of physiological sciences : JPS2014
Ex vivo cultured neuronal networks emit in vivo-like spontaneous activity.
Article in The journal of physiological sciences : JPS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Physiologically Relevant Organotypic Tissue Slice Model for Evaluating Cell Responses to Ionizing Radiation.International journal of molecular sciences · 2026Review
- Atypical plume-like events contribute to glutamate accumulation in metabolic stress conditions.iScience · 2025Article
- Specific AAV2/PHP.eB-mediated gene transduction of CA2 pyramidal cells via injection into the lateral ventricle.Scientific reports · 2023Article
- Long-Lived Organotypic Slice Culture Model of the Rat Basolateral Amygdala.Current protocols · 2021Article
- Functional Multiple-Spine Calcium Imaging from Brain Slices.STAR protocols · 2020Article
- Locally sequential synaptic reactivation during hippocampal ripples.Science advances · 2020Article
- Rescue of hyperexcitability in hippocampal CA1 neurons from Mecp2 (-/y) mouse through surface potential neutralization.PloS one · 2018Article
- The role of dimensionality in neuronal network dynamics.Scientific reports · 2016Article
- Simultaneous silence organizes structured higher-order interactions in neural populations.Scientific reports · 2015Article
- Quantitative differences in developmental profiles of spontaneous activity in cortical and hippocampal cultures.Neural development · 2015Article
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Authors and funding
9 authors.
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Abstract
Spontaneous neuronal activity is present in virtually all brain regions, but neither its function nor spatiotemporal patterns are fully understood. Ex vivo organotypic slice cultures may offer an opportunity to investigate some aspects of spontaneous activity, because they self-restore their networks that collapsed during slicing procedures. In hippocampal networks, we compared the levels and patterns of in vivo spontaneous activity to those in acute and cultured slices. We found that the firing rates and excitatory synaptic activity in the in vivo hippocampus are more similar to those in slice cultures compared to acute slices. The soft confidence-weighted algorithm, a machine learning technique without human bias, also revealed that hippocampal slice cultures resemble the in vivo hippocampus in terms of the overall tendency of the parameters of spontaneous activity.
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