ArticleRadiographics : a review publication of the Radiological Society of North America, Inc
Diffusion-weighted MR imaging for characterizing musculoskeletal lesions.
Article in Radiographics : a review publication of the Radiological Society of North America, Inc. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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69 citing papers in PubMed.
- Apparent diffusion coefficient metrics for treatment response assessment in soft tissue sarcoma: Reproducibility and prognostic value of whole-tumor and sub-regional analysis.Skeletal radiology · 2026Article
- MRI findings for differentiating benign and malignant soft tissue tumors: a narrative review- Part 1: diagnostic performance.Skeletal radiology · 2026Review
- The quiet flame: whole-body MRI and the underestimated burden of pediatric chronic non-bacterial osteomyelitis (CNO).European journal of pediatrics · 2026Article
- Diffusion-Weighted Imaging in the Musculoskeletal System: Evolving Role in Modern Imaging Practice.Diagnostics (Basel, Switzerland) · 2026Review
- Case Report: Benign colonic schwannoma with restricted diffusion mimicking malignancy.Frontiers in oncology · 2026Article
- Exploratory quantitative magnetic resonance imaging characterization of histopathologic subtype heterogeneity in osteosarcoma.Polish journal of radiology · 2026Article
- Quantitative MRI Assessment of Bone Marrow Disease in Myelofibrosis: A Prospective Study.Radiology. Imaging cancer · 2025Observational
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- A novel pN stage prediction model for resectable rectal adenocarcinoma based on preoperative MRI features and multiregional apparent diffusion coefficients.European radiology · 2025Article
- Comparison of apparent diffusion coefficients of resectable mid‑high rectal adenocarcinoma and distal paracancerous tissue.Oncology letters · 2025Article
- [Importance and implementation of radiological modalities in the diagnostics of soft tissue tumors].Radiologie (Heidelberg, Germany) · 2024Article
- Quantitative MRI reveals heterogeneous impacts of treatment on diseased bone marrow in a mouse model of myelofibrosis.Magnetic resonance in medicine · 2024Article
- Advanced Magnetic Resonance Imaging and Molecular Imaging of the Painful Knee.Seminars in musculoskeletal radiology · 2023Review
- Pitfalls of Diffusion-Weighted Imaging: Clinical Utility of T2 Shine-through and T2 Black-out for Musculoskeletal Diseases.Diagnostics (Basel, Switzerland) · 2023Review
- The added value of the visual analysis of DWI in post-surgery follow-up of soft tissue sarcoma of the extremities: do we really need ADC?La Radiologia medica · 2023Article
- Diffusion-weighted MRI of total hip arthroplasty for classification of synovial reactions: A pilot study.Magnetic resonance imaging · 2023Article
- Editorial: Imaging of bone cancers - novel methodologies and optimizations.Frontiers in oncology · 2023Article
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- Added value of contrast-enhanced ultrasound to conventional ultrasound for characterization of indeterminate soft-tissue tumors.The British journal of radiology · 2023Article
- Multiparametric MRI to quantify disease and treatment response in mice with myeloproliferative neoplasms.JCI insight · 2022Article
9 more citing papers are in PubMed but not listed here.
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Abstract
Diffusion-weighted (DW) imaging is a functional magnetic resonance (MR) imaging technique that can readily be incorporated into a routine non-contrast material-enhanced MR imaging protocol with little additional scanning time. DW imaging is based on changes in the Brownian motion of water molecules caused by tissue microstructure. The apparent diffusion coefficient (ADC) is a quantitative measure of Brownian movement: Low ADC values typically reflect highly cellular microenvironments in which diffusion is restricted by the presence of cell membranes, whereas acellular regions allow free diffusion and result in elevated ADC values. Thus, with ADC mapping, one may derive useful quantitative information regarding the cellularity of a musculoskeletal lesion using a nonenhanced technique. The role of localized DW imaging in differentiating malignant from benign osseous and soft-tissue lesions is still evolving; when carefully applied, however, this modality has proved helpful in a subset of tumor types, such as nonmyxoid soft-tissue tumors. Studies of the use of DW imaging in assessing the treatment response of both osseous and soft-tissue tumors have shown that higher ADC values correlate with better response to cytotoxic therapy. Successful application of DW imaging in the evaluation of musculoskeletal lesions requires familiarity with potential diagnostic pitfalls that stem from technical artifacts and confounding factors unrelated to lesion cellularity. Further investigation is needed to evaluate the impact of DW imaging-ADC mapping on management and outcome in patients with musculoskeletal lesions.
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