ArticleAnalytical chemistry2014
Development of a GC/Quadrupole-Orbitrap mass spectrometer, part I: design and characterization.
Article in Analytical chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 93 citations in OpenAlex.
- Comprehensive characterisation of organic pollutants in high-polluted sediments and gull eggs using a broad-scope gas chromatography-Orbitrap methodology.Analytical and bioanalytical chemistry · 2026Article
- Nontargeted Screening in Environmental Monitoring Programs: An Update.Advances in experimental medicine and biology · 2026Review
- Chemical Exposomics in Human Plasma by Lipid Removal and Large-Volume Injection Gas Chromatography-High-Resolution Mass Spectrometry.Environmental science & technology · 2024Article
- Instrumentation at the Leading Edge of Proteomics.Analytical chemistry · 2024Review
- Derivatization-Enhanced Analysis of Glucocorticoids for Structural Characterization by Gas Chromatography-Orbitrap High-Resolution Mass Spectrometry.Molecules (Basel, Switzerland) · 2023Article
- A high-resolution Orbitrap Mass spectral library for trace volatile compounds in fruit wines.Scientific data · 2022Article
- Advances in Plant Metabolomics and Its Applications in Stress and Single-Cell Biology.International journal of molecular sciences · 2022Review
- Article
- pyAIR-A New Software Tool for Breathomics Applications-Searching for Markers in TD-GC-HRMS Analysis.Molecules (Basel, Switzerland) · 2022Article
- Targeted and Nontargeted Detection and Characterization of Trace Organic Chemicals in Human Serum and Plasma Using QuEChERS Extraction.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- A scalable workflow to characterize the human exposome.Nature communications · 2021Article
- A two-step gas chromatography-tandem mass spectrometry method for measurement of multiple environmental pollutants in human plasma.Environmental science and pollution research international · 2021Article
- Open, High-Resolution EI+ Spectral Library of Anthropogenic Compounds.Frontiers in public health · 2021Article
- High Resolution GC-Orbitrap-MS Metabolomics Using Both Electron Ionization and Chemical Ionization for Analysis of Human Plasma.Journal of proteome research · 2020Article
- Metabolomics Benefits from Orbitrap GC-MS-Comparison of Low- and High-Resolution GC-MS.Metabolites · 2020Article
- Design and Evaluation of a Gas Chromatograph-Atmospheric Pressure Chemical Ionization Interface for an Exactive Orbitrap Mass Spectrometer.Journal of the American Society for Mass Spectrometry · 2019Article
- Gas-Phase Chemistry in the GC Orbitrap Mass Spectrometer.Journal of the American Society for Mass Spectrometry · 2019Article
- High-resolution gas chromatography/mass spectrometry metabolomics of non-human primate serum.Rapid communications in mass spectrometry : RCM · 2018Article
- A path to the powerhouse: systems-to-structure approaches for studying mitochondrial proteins.Protein science : a publication of the Protein Society · 2018Article
- Production system influences volatile biomarkers in tomato.Metabolomics : Official journal of the Metabolomic Society · 2018Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
Identification of unknown compounds is of critical importance in GC/MS applications (metabolomics, environmental toxin identification, sports doping, petroleomics, and biofuel analysis, among many others) and remains a technological challenge. Derivation of elemental composition is the first step to determining the identity of an unknown compound by MS, for which high accuracy mass and isotopomer distribution measurements are critical. Here, we report on the development of a dedicated, applications-grade GC/MS employing an Orbitrap mass analyzer, the GC/Quadrupole-Orbitrap. Built from the basis of the benchtop Orbitrap LC/MS, the GC/Quadrupole-Orbitrap maintains the performance characteristics of the Orbitrap, enables quadrupole-based isolation for sensitive analyte detection, and includes numerous analysis modalities to facilitate structural elucidation. We detail the design and construction of the instrument, discuss its key figures-of-merit, and demonstrate its performance for the characterization of unknown compounds and environmental toxins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.