ArticleConnective tissue research2015
Roles of TGF-β/Smad signaling pathway in pathogenesis and development of gluteal muscle contracture.
Article in Connective tissue research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Gluteal Fibrosis and Its Surgical Treatment.The Journal of bone and joint surgery. American volume · 2019Pooled it
- LncRNA MALAT1 Knockdown Alleviates Fibrogenic Response in Human Endometrial Stromal Cells Via the miR-22-3p/TGFβR1/Smad2/3 Pathway.Cell biochemistry and biophysics · 2024Article
- Cellular and Molecular Mechanisms of Hypertrophy of Ligamentum Flavum.Biomolecules · 2024Review
- TGF-β signaling in health, disease, and therapeutics.Signal transduction and targeted therapy · 2024Review
- miR-491-5p inhibits Emilin 1 to promote fibroblasts proliferation and fibrosis in gluteal muscle contracture via TGF-Beta1/Smad2 pathway.Physiological research · 2022Article
- Spinal-pelvic sagittal parameters in patients with gluteal muscle contracture: an imaging study.PeerJ · 2022Article
- miR-29a is a potential protective factor for fibrogenesis in gluteal muscle contracture.Physiological research · 2020Article
- A possible prediction of dystocia at the time of cesarean delivery: Gluteal muscle contracture, a single center experience from China.Medicine · 2020Observational
- Histology and molecular pathology of iliotibial tract contracture in patients with gluteal muscle contracture.Bioscience reports · 2019Article
- The role of arthroscopic release of gluteal muscle contracture in improving patellofemoral instability.Journal of orthopaedic surgery and research · 2019Article
- The role of KDR in intrauterine adhesions may involve the TGF-β1/Smads signaling pathway.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2019Article
- Burden of gluteal fibrosis and post-injection paralysis in the children of Kumi District in Uganda.BMC musculoskeletal disorders · 2018Article
- Comparison of the clinical effects of arthroscopic surgery vs. open surgery for grade II gluteal muscle contracture in adults.Experimental and therapeutic medicine · 2018Article
- Midazolam inhibits chondrogenesis via peripheral benzodiazepine receptor in human mesenchymal stem cells.Journal of cellular and molecular medicine · 2018Article
- Arthroscopic revision release of gluteal muscle contracture after failed primary open surgery.International orthopaedics · 2017Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of the studyGluteal muscle contracture (GMC) is a chronic fibrotic disease of gluteal muscles which is characterized by excessive deposition of collagen in the extracellular matrix. Transforming growth factor (TGF)-βs have been shown to play an important role in the progression of GMC. However, the underlying mechanisms are not entirely clear. We sought to explore the expression of TGF-β/Smad pathway proteins and their downstream targets in gluteal muscle contracture disease. MATERIALS AND
methodsThe expression levels of collagens type I/III, TGF-β1, Smad2/3/4/7 and PAI-1 (plasminogen activator inhibitor type 1) in gluteal muscle contraction (GMC) patients were measured using immunohistochemistry, reverse transcription and polymerase chain reaction (RT-PCR) and western blot assays.
resultsThe expressions of collagens type I/III and TGF-β1 were significantly increased in the contraction band compared with unaffected muscle. In addition, R-Smad phosphorylation and Smad4 protein expression in the contraction band were also elevated, while the expression of Smad7 was significantly decreased in the fibrotic muscle of the GMC patients compared to the unaffected adjacent muscle. The protein and mRNA levels of PAI-1 were also remarkably increased in the contraction band compared with adjacent muscle. Immunohistochemical analysis also demonstrated that the expression levels of TGF-β1 and PAI-1 were higher in contraction band than those in the adjacent muscle.
conclusionOur data confirm the stimulating effects of the TGF-β/Smad pathway in gluteal muscle contracture disease and reveal the internal changes of TGF-β/Smad pathway proteins and their corresponding targets in gluteal muscle contracture patients.
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