ArticleEuropean journal of psychotraumatology2014
Biomarkers for combat-related PTSD: focus on molecular networks from high-dimensional data.
Article in European journal of psychotraumatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Hyperarousal, Dissociation, Emotion Dysregulation and Re-Experiencing-Towards Understanding Molecular Aspects of PTSD Symptoms.International journal of molecular sciences · 2025Review
- Identifying behavior regulatory leverage over mental disorders transcriptomic network hubs toward lifestyle-dependent psychiatric drugs repurposing.Human genomics · 2025Article
- Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits.Nature reviews. Neurology · 2022Review
- Translating Molecular and Neuroendocrine Findings in Posttraumatic Stress Disorder and Resilience to Novel Therapies.Biological psychiatry · 2019Review
- Animal models of PTSD: a challenge to be met.Molecular psychiatry · 2019Review
- Polygenic risk associated with post-traumatic stress disorder onset and severity.Translational psychiatry · 2019Article
- A decennial review of psychotraumatology: what did we learn and where are we going?European journal of psychotraumatology · 2019Article
- Blunted Nocturnal Salivary Melatonin Secretion Profiles in Military-Related Posttraumatic Stress Disorder.Frontiers in psychiatry · 2019Article
- Short overview on metabolomic approach and redox changes in psychiatric disorders.Redox biology · 2018Review
- Effect of cyclooxygenase‑2 inhibition on the development of post‑traumatic stress disorder in rats.Molecular medicine reports · 2018Article
- Circulating miRNA associated with posttraumatic stress disorder in a cohort of military combat veterans.Psychiatry research · 2017Article
- Systematic search of Bayesian statistics in the field of psychotraumatology.European journal of psychotraumatology · 2017Article
- Diagnostic Biomarkers for Posttraumatic Stress Disorder: Promising Horizons from Translational Neuroscience Research.Biological psychiatry · 2015Review
- PTSD in the military: special considerations for understanding prevalence, pathophysiology and treatment following deployment.European journal of psychotraumatology · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Posttraumatic stress disorder (PTSD) and other deployment-related outcomes originate from a complex interplay between constellations of changes in DNA, environmental traumatic exposures, and other biological risk factors. These factors affect not only individual genes or bio-molecules but also the entire biological networks that in turn increase or decrease the risk of illness or affect illness severity. This review focuses on recent developments in the field of systems biology which use multidimensional data to discover biological networks affected by combat exposure and post-deployment disease states. By integrating large-scale, high-dimensional molecular, physiological, clinical, and behavioral data, the molecular networks that directly respond to perturbations that can lead to PTSD can be identified and causally associated with PTSD, providing a path to identify key drivers. Reprogrammed neural progenitor cells from fibroblasts from PTSD patients could be established as an in vitro assay for high throughput screening of approved drugs to determine which drugs reverse the abnormal expression of the pathogenic biomarkers or neuronal properties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.