ArticleNeural regeneration research2014
Acrylamide exposure impairs blood-cerebrospinal fluid barrier function.
Article in Neural regeneration research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 32 citations in OpenAlex.
- Metabolome informs about the chemical exposome and links to brain health.Environment international · 2025Review
- The presence of a foramen of Luschka in the American alligator (Alligator mississippiensis) and the continuity of the intraventricular and subdural spaces.Journal of anatomy · 2024Article
- Acrylamide inhibits long-term potentiation and learning involving microglia and pro-inflammatory signaling.Scientific reports · 2022Article
- Carvedilol attenuates acrylamide-induced brain damage through inhibition of oxidative, inflammatory, and apoptotic mediators.Iranian journal of basic medical sciences · 2022Article
- The potential neuroprotective effect of allicin and melatonin in acrylamide-induced brain damage in rats.Environmental science and pollution research international · 2021Article
- Therapeutic potential of N-acetylcysteine in acrylamide acute neurotoxicity in adult zebrafish.Scientific reports · 2019Article
- Toxic effect of acrylamide on the development of hippocampal neurons of weaning rats.Neural regeneration research · 2017Article
- Dietary acrylamide exposure was associated with mild cognition decline among non-smoking Chinese elderly men.Scientific reports · 2017Article
- Protective effect of rosemary on acrylamide motor neurotoxicity in spinal cord of rat offspring: postnatal follow-up study.Anatomy & cell biology · 2016Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies show that chronic acrylamide exposure leads to central and peripheral neu-ropathy. However, the underlying mechanisms remained unclear. In this study, we examined the permeability of the blood-cerebrospinal fluid barrier, and its ability to secrete transthyretin and transport leptin of rats exposed to acrylamide for 7, 14, 21 or 28 days. Transthyretin levels in cerebrospinal fluid began to decline on day 7 after acrylamide exposure. The sodium fluorescein level in cerebrospinal fluid was increased on day 14 after exposure. Evans blue concentration in cerebrospinal fluid was increased and the cerebrospinal fluid/serum leptin ratio was decreased on days 21 and 28 after exposure. In comparison, the cerebrospinal fluid/serum albumin ratio was increased on day 28 after exposure. Our findings show that acrylamide exposure damages the blood-cerebrospinal fluid barrier and impairs secretory and transport functions. These changes may underlie acrylamide-induced neurotoxicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.