Evidence map›Paper›PMID 25206827›Full record

ArticleNeural regeneration research2014

The Pael-R gene does not mediate the changes in rotenone-induced Parkinson's disease model cells.

Ting Zou, Xiangqi Tang, Zhiling Huang, Niangui Xu, Zhiping Hu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural regeneration research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ting ZouDepartment of Neurology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Xiangqi TangDepartment of Neurology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Zhiling HuangDepartment of Neurology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Niangui XuDepartment of Neurology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Zhiping HuDepartment of Neurology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Second Xiangya Hospital of Central South University · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we established cell models for Parkinson's disease using rotenone. An RNA interference vector targeting Parkin-associated endothelin receptor-like receptor (Pael-R) was transfected into the model cells. The results of reverse-transcription polymerase chain reaction and western blot analysis showed that Pael-R expression was decreased after RNA interference compared with the control group (no treatment) and the model group (rotenone treatment), while the rate of apoptosis and survival of dopaminergic cells did not differ significantly between groups, as detected by flow cytometry and an MTT assay. These experimental findings indicate that the Pael-R gene has no role in the changes in rotenone-induced Parkinson's disease model cells.

Indexed as

apoptosismitochondrianerve regenerationneural regenerationneurodegenerationPael-RParkinson's diseaseRNA interferencerotenone

Identifiers

PMID25206827
PMCPMC4146201
OpenAlexW2033818985

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.