ArticleNeural regeneration research2014
A non-invasive, rapid method to genotype late-onset Alzheimer's disease-related apolipoprotein E gene polymorphisms.
Article in Neural regeneration research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- The quest for synergy between physical exercise and cognitive stimulation via exergaming in people with dementia: a randomized controlled trial.Alzheimer's research & therapy · 2019Trial
- The effect of an interactive cycling training on cognitive functioning in older adults with mild dementia: study protocol for a randomized controlled trial.BMC geriatrics · 2017Trial
- Clinical Significance of APOE4 Genotyping: Potential for Personalized Therapy and Early Diagnosis of Alzheimer's Disease.Journal of clinical medicine · 2025Review
- Gut microbiota distinguishes aging hispanics with Alzheimer's disease: associations with cognitive impairment and severity.Scientific reports · 2025Article
- Modeling genotype-protein interaction and correlation for Alzheimer's disease: a multi-omics imaging genetics study.Briefings in bioinformatics · 2024Article
- Evaluation of the Polygenic Risk Score for Alzheimer's Disease in Russian Patients with Dementia Using a Low-Density Hydrogel Oligonucleotide Microarray.International journal of molecular sciences · 2023Article
- Performance of plasma Aβ42/40, measured using a fully automated immunoassay, across a broad patient population in identifying amyloid status.Alzheimer's research & therapy · 2023Article
- Regenerative medicine improve neurodegenerative diseases.Cell and tissue banking · 2023Review
- inMTSCCA: An Integrated Multi-task Sparse Canonical Correlation Analysis for Multi-omic Brain Imaging Genetics.Genomics, proteomics & bioinformatics · 2023Article
- Suicide-Related Single Nucleotide Polymorphisms,Genes · 2022Article
- Positive Effect of Cognitive Training in Older Adults with DifferentDiagnostics (Basel, Switzerland) · 2022Article
- Prognosis of Alzheimer's Disease Using Quantitative Mass Spectrometry of Human Blood Plasma Proteins and Machine Learning.International journal of molecular sciences · 2022Article
- Training Computers to See the Built Environment Related to Physical Activity: Detection of Microscale Walkability Features Using Computer Vision.International journal of environmental research and public health · 2022Article
- Matrix metalloproteinase-degraded type I collagen is associated withNeurology. Genetics · 2020Article
- Identifying diagnosis-specific genotype-phenotype associations via joint multitask sparse canonical correlation analysis and classification.Bioinformatics (Oxford, England) · 2020Article
- Characteristics and advantages of adeno-associated virus vector-mediated gene therapy for neurodegenerative diseases.Neural regeneration research · 2019Review
- Cardiovascular Pharmacogenomics and Cognitive Function in Patients with Schizophrenia.Pharmacotherapy · 2017Article
- Apolipoprotein E genotyping using PCR-GoldMag lateral flow assay and its clinical applications.Molecular medicine reports · 2016Article
- Apolipoprotein E polymorphisms increase the risk of post-stroke depression.Neural regeneration research · 2016Article
- A rapid and cost-effective method for genotyping apolipoprotein E gene polymorphism.Molecular neurodegeneration · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The apolipoprotein E gene ε4 allele is considered a negative factor for neural regeneration in late-onset Alzheimer's disease cases. The aim of this study was to establish a non-invasive, rapid method to genotype apolipoprotein E gene polymorphisms. Genomic DNA from mouth swab specimens was extracted using magnetic nanoparticles, and genotyping was performed by real-time PCR using TaqMan-BHQ probes. Genotyping accuracy was validated by DNA sequencing. Our results demonstrate 100% correlation to DNA sequencing, indicating reliability of our protocol. Thus, the method we have developed for apolipoprotein E genotyping is accurate and reliable, and also suitable for genotyping large samples, which may help determine the role of the apolipoprotein E ε4 allele in neural regeneration in late-onset Alzheimer's disease cases.
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