ArticleNeural regeneration research2013
Sericin protects against diabetes-induced injuries in sciatic nerve and related nerve cells.
Article in Neural regeneration research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Sericin Protein: Structure, Properties, and Applications.Journal of functional biomaterials · 2024Review
- Silk Sericin: A Promising Sustainable Biomaterial for Biomedical and Pharmaceutical Applications.Polymers · 2022Review
- Review
- Enhancing the In Vitro Biological Activity of Degraded Silk Sericin and Its Analog Metabolites.Biomolecules · 2022Article
- Low Molecular Weight Sericin Enhances theFrontiers in bioengineering and biotechnology · 2022Article
- Localized Delivery of Drugs through Medical Textiles for Treatment of Burns: A Perspective Approach.Advanced pharmaceutical bulletin · 2021Review
- The flavonoid-rich ethanolic extract from the green cocoon shell of silkworm has excellent antioxidation, glucosidase inhibition, and cell protective effectsFood & nutrition research · 2020Article
- Identification and applications of neuroactive silk proteins: a narrative review.Journal of applied biomedicine · 2019Review
- Therapeutic effects of ethanolic extract from the green cocoon shell of silkwormToxicology research · 2019Article
- Novel nutraceutic therapies for the treatment of metabolic syndrome.World journal of diabetes · 2016Review
- A new estimation of the total flavonoids in silkworm cocoon sericin layer through aglycone determination by hydrolysis-assisted extraction and HPLC-DAD analysis.Food & nutrition research · 2016Article
- Silkworm Sericin: Properties and Biomedical Applications.BioMed research international · 2016Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sericin from discarded silkworm cocoons of silk reeling has been used in different fields, such as cosmetology, skin care, nutrition, and oncology. The present study established a rat model of type 2 diabetes by consecutive intraperitoneal injections of low-dose (25 mg/kg) streptozotocin. After intragastrical perfusion of sericin for 35 days, blood glucose levels significantly declined, and the expression of neurofilament protein in the sciatic nerve and nerve growth factor in L4-6 spinal ganglion and anterior horn cells significantly increased. However, the expression of neuropeptide Y in spinal ganglion and anterior horn cells significantly decreased in model rats. These findings indicate that sericin protected the sciatic nerve and related nerve cells against injury in a rat type 2 diabetic model by upregulating the expression of neurofilament protein in the sciatic nerve and nerve growth factor in spinal ganglion and anterior horn cells, and downregulating the expression of neuropeptide Y in spinal ganglion and anterior horn cells.
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Registered trials
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