Evidence map›Paper›PMID 25206590›Full record

ArticleNeural regeneration research2013

Tall gastrodis tuber combined with antiepileptic drugs repairs abnormal perfusion foci in focal epilepsy.

Weimin Wang, Zhenyu Fan, Yongqin Zhang, Yuxia Yang, Yaqing Liu, Xiaoli Dang, Wenjun Song, Yinping Wu, Jiang Ye

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural regeneration research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Weimin WangEpilepsy Center, Second Hospital, Lanzhou University, Gansu Provincial Center for Prevention and Treatment of Epilepsy, Lanzhou 730030, Gansu Province, China.
Zhenyu FanEpilepsy Center, Second Hospital, Lanzhou University, Gansu Provincial Center for Prevention and Treatment of Epilepsy, Lanzhou 730030, Gansu Province, China.
Yongqin ZhangEpilepsy Center, Second Hospital, Lanzhou University, Gansu Provincial Center for Prevention and Treatment of Epilepsy, Lanzhou 730030, Gansu Province, China.
Yuxia YangEpilepsy Center, Second Hospital, Lanzhou University, Gansu Provincial Center for Prevention and Treatment of Epilepsy, Lanzhou 730030, Gansu Province, China.
Yaqing LiuEpilepsy Center, Second Hospital, Lanzhou University, Gansu Provincial Center for Prevention and Treatment of Epilepsy, Lanzhou 730030, Gansu Province, China.
Xiaoli DangEpilepsy Center, Second Hospital, Lanzhou University, Gansu Provincial Center for Prevention and Treatment of Epilepsy, Lanzhou 730030, Gansu Province, China.
Wenjun SongEpilepsy Center, Second Hospital, Lanzhou University, Gansu Provincial Center for Prevention and Treatment of Epilepsy, Lanzhou 730030, Gansu Province, China.
Yinping WuEpilepsy Center, Second Hospital, Lanzhou University, Gansu Provincial Center for Prevention and Treatment of Epilepsy, Lanzhou 730030, Gansu Province, China.
Jiang YeEpilepsy Center, Second Hospital, Lanzhou University, Gansu Provincial Center for Prevention and Treatment of Epilepsy, Lanzhou 730030, Gansu Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One hundred patients with focal epilepsy were recruited for the present study and their seizures controlled with antiepileptic drugs. The patients then orally received a capsule of tall gastrodis tuber powder, a traditional Chinese drug, and underwent single photon emission computed tomography, long-term electroencephalogram, and CT/MRI. Blood drug levels were monitored throughout the study. Before treatment with tall gastrodis tuber, 35 of the 100 cases had abnormal CT/MRI scans; 79 cases had abnormal single photon emission computed tomography images; 86 cases had abnormal electroencephalogram; and a total of 146 abnormal perfusion foci were observed across the 100 subjects. After treatment, the number of patients with normal single photon emission computed tomography images increased by 12; normal electroencephalogram was observed in an additional 27 cases and the number of patients with epileptiform discharge decreased by 29 (34% of 86); the total number of abnormal perfusion foci decreased by 52 (36%) and changes in abnormal foci were visible in 65 patients. These changes indicate that the administration of tall gastrodis tuber in combination with antiepileptic drugs repairs abnormal perfusion foci in patients with focal epilepsy. Our results demonstrate that traditional Chinese drugs can repair abnormal perfusion foci and, as such, are a promising new pathway in the treatment of focal epilepsy.

Indexed as

abnormal perfusion focusantiepileptic drugsbrain injurycombination therapyfocal epilepsygrant-supported paperlong-term vigilance-controlled electroencephalogramneuoregenerationneural regenerationneuroimagingphotographs-containing paperregion of interestsingle photon emission computed tomographytall gastrodis tubertraditional Chinese medicine

Identifiers

PMID25206590
PMCPMC4107520

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.