ArticleNeural regeneration research2013
Metformin inhibits food intake and neuropeptide Y gene expression in the hypothalamus.
Article in Neural regeneration research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Effects of metformin on energy intake and satiety in obese children.Diabetes, obesity & metabolism · 2015Trial
- Exercise attenuates cisplatin-induced anorexia-cachexia via modulation of hypothalamic inflammation and orexigenic signaling.European journal of applied physiology · 2026Article
- Novel Therapeutic Strategies for Obesity-Related Glomerulopathy.Current hypertension reports · 2025Review
- Hypothalamic AMP-Activated Protein Kinase as a Whole-Body Energy Sensor and Regulator.Endocrinology and metabolism (Seoul, Korea) · 2024Article
- Olanzapine, risperidone and ziprasidone differently affect lysosomal function and autophagy, reflecting their different metabolic risk in patients.Translational psychiatry · 2024Article
- The function, mechanisms, and clinical applications of metformin: potential drug, unlimited potentials.Archives of pharmacal research · 2023Review
- Metformin and alpha lipoic acid ameliorate hypothyroidism and its complications in adult male rats.Journal of diabetes and metabolic disorders · 2022Article
- Metformin in nucleus accumbens core reduces cue-induced cocaine seeking in male and female rats.Addiction biology · 2022Article
- Hypothalamic miR-1983 Targets Insulin Receptor β and the Insulin-mediated miR-1983 Increase Is Blocked by Metformin.Endocrinology · 2022Article
- Metformin Treatment Attenuates Brain Inflammation and Rescues PACAP/VIP Neuropeptide Alterations in Mice Fed a High-Fat Diet.International journal of molecular sciences · 2021Article
- Metformin effectively restores the HPA axis function in diet-induced obese rats.International journal of obesity (2005) · 2021Article
- Metformin Improves Autonomic Nervous System Imbalance and Metabolic Dysfunction in Monosodium L-Glutamate-Treated Rats.Frontiers in endocrinology · 2021Article
- Asperuloside Enhances Taste Perception and Prevents Weight Gain in High-Fat Fed Mice.Frontiers in endocrinology · 2021Article
- Metformin and Systemic Metabolism.Trends in pharmacological sciences · 2020Review
- Metformin: Mechanisms in Human Obesity and Weight Loss.Current obesity reports · 2019Review
- A Possible Mechanism of Metformin in Improving Insulin Resistance in Diabetic Rat Models.International journal of endocrinology · 2019Article
- Exercise in a Pill: The Latest on Exercise-Mimetics.Brain plasticity (Amsterdam, Netherlands) · 2017Review
- Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice.Behavioural brain research · 2016Article
- Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metformin may reduce food intake and body weight, but the anorexigenic effects of metformin are still poorly understood. In this study, Sprague-Dawley rats were administered a single intracere-broventricular dose of metformin and compound C, in a broader attempt to investigate the regula-tory effects of metformin on food intake and to explore the possible mechanism. Results showed that central administration of metformin significantly reduced food intake and body weight gain, par-ticularly after 4 hours. A reduction of neuropeptide Y expression and induction of AMP-activated protein kinase phosphorylation in the hypothalamus were also observed 4 hours after metformin administration, which could be reversed by compound C, a commonly-used antagonist of AMP-activated protein kinase. Furthermore, metformin also improved lipid metabolism by reducing plasma low-density lipoprotein. Our findings suggest that under normal physiological conditions, central regulation of appetite by metformin is related to a decrease in neuropeptide Y gene expres-sion, and that the activation of AMP-activated protein kinase may simply be a response to the anorexigenic effect of metformin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.