Evidence map›Paper›PMID 25206534›Full record

ArticleNeural regeneration research2013

Degenerative alterations in noradrenergic neurons of the locus coeruleus in Alzheimer's disease.

Lihua Liu, Saiping Luo, Leping Zeng, Weihong Wang, Liming Yuan, Xiaohong Jian

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural regeneration research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 26 citations in OpenAlex.

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  8. Review
  9. Design, synthesis and biological evaluation of novelJournal of enzyme inhibition and medicinal chemistry · 2022
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  20. Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lihua LiuDepartment of Histology & Embryology, School of Basic Medical Sciences, Central South University, Changsha 410013, Hunan Province, China ; Department of Nursing, Medical College of Hunan Normal University, Changsha 10013, Hunan Province, China.
Saiping LuoThird Department of Surgery, Agricultural Division Four Hospital, Xinjiang Production and Construction Corps, Yili 835000, Xinjiang Uygur Autonomous Region, China.
Leping ZengDepartment of Anatomy & Neurobiology, School of Basic Medical Sciences, Central South University, Changsha 410013, Hunan Province, China.
Weihong WangDepartment of Nursing, Medical College of Hunan Normal University, Changsha 10013, Hunan Province, China.
Liming YuanDepartment of Anatomy, Medical College of Hunan Normal University, Changsha 410013, Hunan Province, China.
Xiaohong JianDepartment of Anatomy, Medical College of Hunan Normal University, Changsha 410013, Hunan Province, China.
Hunan Normal University · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mice carrying mutant amyloid-β precursor protein and presenilin-1 genes (APP/PS1 double transgenic mice) have frequently been used in studies of Alzheimer's disease; however, such studies have focused mainly on hippocampal and cortical changes. The severity of Alzheimer's disease is known to correlate with the amount of amyloid-β protein deposition and the number of dead neurons in the locus coeruleus. In the present study, we assigned APP/PS1 double transgenic mice to two groups according to age: young mice (5-6 months old) and aged mice (16-17 months old). Age-matched wild-type mice were used as controls. Immunohistochemistry for tyrosine hydroxylase (a marker of catecholaminergic neurons in the locus coeruleus) revealed that APP/PS1 mice had 23% fewer cells in the locus coeruleus compared with aged wild-type mice. APP/PS1 mice also had increased numbers of cell bodies of neurons positive for tyrosine hydroxylase, but fewer tyrosine hydroxylase-positive fibers, which were also short, thick and broken. Quantitative analysis using unbiased stereology showed a significant age-related increase in the mean volume of tyrosine droxylase-positive neurons in aged APP/PS1 mice compared with young APP/PS1 mice. Moreover, the mean volume of tyrosine hydroxylase-positive neurons was positively correlated with the total volume of the locus coeruleus. These findings indicate that noradrenergic neurons and fibers in the locus coeruleus are predisposed to degenerative alterations in APP/PS1 double transgenic mice.

Indexed as

Alzheimer's diseasegrants-supported paperlocus coeruleusneural regenerationneuroregenerationno-radrenergic neuronpresenilin-1senile plaquestyrosine hydroxylaseβ-amyloid

Identifiers

PMID25206534
PMCPMC4146034
OpenAlexW2268956507

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.