Evidence map›Paper›PMID 25206533›Full record

ArticleNeural regeneration research2013

Combined transplantation of GDAs(BMP) and hr-decorin in spinal cord contusion repair.

Liang Wu, Jianjun Li, Liang Chen, Hong Zhang, Li Yuan, Stephen Ja Davies

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural regeneration research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Cell transplantation to repair the injured spinal cord.International review of neurobiology · 2022
    Article
  4. Article
  5. Review
  6. Review
  7. Hormonal therapy in traumatic spinal cord injury.American journal of translational research · 2017
    Review
  8. Review
  9. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Liang WuSchool of Rehabilitation Medicine, Capital Medical University, Beijing 100068, China ; Department of Neural Functional Reconstruction of Spine and Spinal Cord, China Rehabilitation Research Center, Beijing 100068, China ; Rehabilitation Center, Beijing Xiaotangshan Rehabilitation Hospital, Beijing 102211, China.
Jianjun LiSchool of Rehabilitation Medicine, Capital Medical University, Beijing 100068, China ; Department of Neural Functional Reconstruction of Spine and Spinal Cord, China Rehabilitation Research Center, Beijing 100068, China.
Liang ChenSchool of Rehabilitation Medicine, Capital Medical University, Beijing 100068, China ; Department of Neural Functional Reconstruction of Spine and Spinal Cord, China Rehabilitation Research Center, Beijing 100068, China.
Hong ZhangSchool of Rehabilitation Medicine, Capital Medical University, Beijing 100068, China.
Li YuanSchool of Rehabilitation Medicine, Capital Medical University, Beijing 100068, China ; Department of Neural Functional Reconstruction of Spine and Spinal Cord, China Rehabilitation Research Center, Beijing 100068, China.
Stephen Ja DaviesDepartment of Neurosurgery, University of Colorado Denver, 1250 14th Street Denver, Colorado 80217, USA.
Capital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Following spinal cord injury, astrocyte proliferation and scar formation are the main factors inhibiting the regeneration and growth of spinal cord axons. Recombinant decorin suppresses inflammatory reactions, inhibits glial scar formation, and promotes axonal growth. Rat models of T8 spinal cord contusion were created with the NYU impactor and these models were subjected to combined transplantation of bone morphogenetic protein-4-induced glial-restricted precursor-derived astrocytes and human recombinant decorin transplantation. At 28 days after spinal cord contusion, double-immunofluorescent histochemistry revealed that combined transplantation inhibited the early inflammatory response in injured rats. Furthermore, brain-derived neurotrophic factor, which was secreted by transplanted cells, protected injured axons. The combined transplantation promoted axonal regeneration and growth of injured motor and sensory neurons by inhibiting astrocyte proliferation and glial scar formation, with astrocytes forming a linear arrangement in the contused spinal cord, thus providing axonal regeneration channels.

Indexed as

astrocytesbrain-derived growth factorcombined trans-plantationglial cellsglial fibrillary acidic proteinglial progenitor cellsglial scargrants-supported paperhuman recombinant decorinneural regenerationneural stem cellsneuroregenerationspinal cord injury

Identifiers

PMID25206533
PMCPMC4146032
OpenAlexW1514632242

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.