Evidence map›Paper›PMID 25206461›Full record

ArticleNeural regeneration research2013

Radix Achyranthis Bidentatae improves learning and memory capabilities in ovariectomized rats.

Yuefen Wang, Ya Xu, Yanshu Pan, Weihong Li, Wei Zhang, Yang Liu, Jing Jia, Pengtao Li

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural regeneration research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yuefen WangDepartment of Encephalopathy, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100017, China.
Ya XuDepartment of Basic Chinese Medicine, School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100029, China.
Yanshu PanPathology Room, Department of Human Morphology, School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100029, China.
Weihong LiMedical Comprehensive Course Teaching Center, School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100029, China.
Wei ZhangAnatomy Room, Department of Human Morphology, School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100029, China.
Yang LiuPathology Room, Department of Human Morphology, School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100029, China.
Jing JiaPathology Room, Department of Human Morphology, School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100029, China.
Pengtao LiDepartment of Encephalopathy, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100017, China.
Beijing University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kidney-tonifying recipe can reduce the accumulation of advanced glycation end products, prevent neuronal degeneration and improve cognitive functions in ovariectomized rats. Radix Achyranthis Bidentatae alcohol extracts may dose-dependently inhibit non-enzymatic saccharification in vitro. This study aimed to examine the effect of Radix Achyranthis Bidentatae on advanced glycation end products and on learning and memory capabilities in ovariectomized rats. Ovariectomized rats were treated with Radix Achyranthis Bidentatae alcohol extracts (containing 1.5 g/kg crude drug) or 0.1% aminoguanidine for 12 weeks and behavioral testing was performed with the Y-electrical maze. This test revealed that Radix Achyranthis Bidentatae and aminoguanidine could improve the learning and memory capabilities of ovariectomized rats. Results of competitive enzyme-linked immunosorbent assay showed that treatment with Radix Achyranthis Bidentatae or aminoguanidine reduced the accumulation of advanced glycation end products in the frontal cortex of ovariectomized rats, while increasing content in the blood and urine. Biochemical tests showed that treatment with Radix Achyranthis Bidentatae or aminoguanidine decreased superoxide dismutase activity in the serum and frontal cortex, and increased serum levels of glutathione peroxidase in ovariectomized rats. In addition, there was no apparent effect on malondialdehyde levels. These experimental findings indicate that Radix Achyranthis Bidentatae inhibits production of advanced glycation end products and its accumulation in brain tissue, and improves learning and memory capabilities in ovariectomized rats. These effects may be associated with an anti-oxidative action of the extract.

Indexed as

advanced glycation end productsAlzheimer's diseasecognitiongrants-supported paperlearning and memoryneural regenerationneuroregenerationovariectomyoxidative stressRadix Achyranthis Bidentataetraditional Chinese medicine

Identifiers

PMID25206461
PMCPMC4145912
OpenAlexW1517958355

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.