Evidence map›Paper›PMID 25206436›Full record

ArticleNeural regeneration research2013

Angiotensin-converting enzyme gene polymorphism and middle cerebral artery stenosis in a Chinese Han population.

Chunshu Rong, Yingqi Xing, Xinmei Jiang, Juan Wang, Baoshan Gao, Jianjun Zhao, Kangding Liu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural regeneration research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Genetic Risk Factors of Intracranial Atherosclerosis.Current atherosclerosis reports · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Chunshu RongDepartment of Encephalopathy, Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130021, Jilin Province, China ; Department of Neurology, First Hospital of Jilin University, Changchun 130021, Jilin Province, China.
Yingqi XingDepartment of Neurology, First Hospital of Jilin University, Changchun 130021, Jilin Province, China.
Xinmei JiangDepartment of Neurology, First Hospital of Jilin University, Changchun 130021, Jilin Province, China.
Juan WangDepartment of Neurology, First Hospital of Jilin University, Changchun 130021, Jilin Province, China.
Baoshan GaoDepartment of Urinary Surgery, First Hospital of Jilin University, Changchun 130021, Jilin Province, China.
Jianjun ZhaoDepartment of Encephalopathy, Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130021, Jilin Province, China.
Kangding LiuDepartment of Neurology, First Hospital of Jilin University, Changchun 130021, Jilin Province, China.
First Hospital of Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The angiotensin-converting enzyme gene is a candidate gene of stroke. The present study involved 62 healthy volunteers and 148 patients with middle cerebral artery stenosis as confirmed by brain color ultrasound from a Han population in North China, and determined the peripheral blood angiotensin-converting enzyme genotype using PCR-restriction fragment length polymorphism analysis. The results showed that the frequencies of the DD genotype and D allele were increased in patients with middle cerebral artery stenosis, but the difference was not statistically significant compared with healthy controls. The findings of this study on the relationship between stroke genes and middle cerebral artery stenosis indicate no significant correlation between the frequencies of the DD genotype and D allele of angiotensin-converting enzyme and middle cerebral artery stenosis in this Han population from North China. In the future, studies will be carried out to investigate correlations between multiple stroke candidate gene synergy and middle cerebral artery stenosis to provide a foundation for the development of gene therapy.

Indexed as

angiostenosisangiotensin-converting enzymebrain injurygeneHan populationmiddle cerebral arteryneural regenerationneuroregenerationNorth Chinapolymorphismstroke

Identifiers

PMID25206436
PMCPMC4107760
OpenAlexW1515472635

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.