Evidence map›Paper›PMID 25206335›Full record

ReviewFrontiers in aging neuroscience2014

Neural correlates of cognitive intervention in persons at risk of developing Alzheimer's disease.

S M Hadi Hosseini, Joel H Kramer, Shelli R Kesler

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in aging neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04959383 (Exergame Balance Training for Pre Frontal Brain Activity and Executive Functioning in Patients With Mild Cognitive Impairment), which is not on this map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04959383 nacompletednot on this mapstarted 2021, after this paper: background citation

Exergame Balance Training for Pre Frontal Brain Activity and Executive Functioning in Patients With Mild Cognitive Impairment

TypeinterventionalSponsorRiphah International UniversityRan2021 to 2022Enrolled90ConditionsMild Cognitive ImpairmentArmsLow complexity Exergaming group, Moderate complexity Exergaming group, High complexity Exergaming group, Control Group
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.

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  4. Training gains and transfer effects after mnemonic strategy training in mild cognitive impairment: A fMRI study.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

S M Hadi HosseiniDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine Stanford, CA, USA.
Joel H KramerDepartment of Neurology, Memory and Aging Center, University of California San Francisco, CA, USA.
Shelli R KeslerDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine Stanford, CA, USA ; Stanford Cancer Institute Palo Alto, CA, USA.
Stanford Cancer InstituteStanford University · USUniversity of California, San Francisco · US

Funding

Very-long Term Neurocognitive Outcomes in Breast Cancer Survivors (ProbC2)R01CA172145 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI KESLER, SHELLI R, PALESH, OXANA G · 2012 to 2024
$3.3M
Multimodal MRI Biomarker of Mild Cognitive Impairment in Breast CancerR01NR014195 · NINR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KESLER, SHELLI R, WEFEL, JEFFREY SCOTT · 2012 to 2017
$2.5M
NCI NIH HHS R01 CA172145NINR NIH HHS R01 NR014195
6 · The paper itself

Abstract

Cognitive training is an emergent approach that has begun to receive increased attention in recent years as a non-pharmacological, cost-effective intervention for Alzheimer's disease (AD). There has been increasing behavioral evidence regarding training-related improvement in cognitive performance in early stages of AD. Although these studies provide important insight about the efficacy of cognitive training, neuroimaging studies are crucial to pinpoint changes in brain structure and function associated with training and to examine their overlap with pathology in AD. In this study, we reviewed the existing neuroimaging studies on cognitive training in persons at risk of developing AD to provide an overview of the overlap between neural networks rehabilitated by the current training methods and those affected in AD. The data suggest a consistent training-related increase in brain activity in medial temporal, prefrontal, and posterior default mode networks, as well as increase in gray matter structure in frontoparietal and entorhinal regions. This pattern differs from the observed pattern in healthy older adults that shows a combination of increased and decreased activity in response to training. Detailed investigation of the data suggests that training in persons at risk of developing AD mainly improves compensatory mechanisms and partly restores the affected functions. While current neuroimaging studies are quite helpful in identifying the mechanisms underlying cognitive training, the data calls for future multi-modal neuroimaging studies with focus on multi-domain cognitive training, network level connectivity, and individual differences in response to training.

Indexed as

agingcognitive stimulationcognitive trainingcomputerized trainingmild cognitive impairment (MCI)neuroimagingplasticity

Identifiers

PMID25206335
PMCPMC4143724
OpenAlexW2025005993

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.