ArticleFrontiers in neural circuits2014
Activity-dependent serotonergic excitation of callosal projection neurons in the mouse prefrontal cortex.
Article in Frontiers in neural circuits, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Pupil-linked arousal heterogeneously modulates cell-type-specific sensory processing.Science advances · 2026Article
- Psychedelic neuroplasticity of cortical neurons lacking 5-HT2A receptors.Molecular psychiatry · 2026Article
- Afferent-specific modulation of excitatory synaptic transmission by acetylcholine and serotonin in the prelimbic cortex.bioRxiv : the preprint server for biology · 2025Article
- Common and contrasting effects of 5-HTergic signaling in pyramidal cells and SOM interneurons of the mouse cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Gain control of sensory input across polysynaptic circuitries in mouse visual cortex by a single G protein-coupled receptor type (5-HTNature communications · 2024Article
- Cellular rules underlying psychedelic control of prefrontal pyramidal neurons.bioRxiv : the preprint server for biology · 2023Article
- Serotonin neurons modulate learning rate through uncertainty.Current biology : CB · 2022Article
- Neocortical layer 5 subclasses: From cellular properties to roles in behavior.Frontiers in synaptic neuroscience · 2022Review
- Subthreshold basis for reward-predictive persistent activity in mouse prefrontal cortex.Cell reports · 2021Article
- International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function.Pharmacological reviews · 2021Review
- Mapping the physiological and molecular markers of stress and SSRI antidepressant treatment in S100a10 corticostriatal neurons.Molecular psychiatry · 2020Article
- Separable gain control of ongoing and evoked activity in the visual cortex by serotonergic input.eLife · 2020Article
- Preferential cholinergic excitation of corticopontine neurons.The Journal of physiology · 2018Article
- Cell-Type Specificity of Callosally Evoked Excitation and Feedforward Inhibition in the Prefrontal Cortex.Cell reports · 2018Article
- Serotonergic Regulation of Corticoamygdalar Neurons in the Mouse Prelimbic Cortex.Frontiers in neural circuits · 2018Article
- Mechanisms Underlying Serotonergic Excitation of Callosal Projection Neurons in the Mouse Medial Prefrontal Cortex.Frontiers in neural circuits · 2018Article
- Serotonin 1B Receptors Regulate Prefrontal Function by Gating Callosal and Hippocampal Inputs.Cell reports · 2016Article
- Serotonin (5-HT) 5-HT2A Receptor (5-HT2AR):5-HT2CR Imbalance in Medial Prefrontal Cortex Associates with Motor Impulsivity.ACS chemical neuroscience · 2015Article
- Editorial: Neuromodulation of executive circuits.Frontiers in neural circuits · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Layer 5 pyramidal neurons (L5PNs) in the mouse prefrontal cortex respond to serotonin (5-HT) according to their long-distance axonal projections; 5-HT1A (1A) receptors mediate inhibitory responses in corticopontine (CPn) L5PNs, while 5-HT2A (2A) receptors can enhance action potential (AP) output in callosal/commissural (COM) L5PNs, either directly (in "COM-excited" neurons), or following brief 1A-mediated inhibition (in "COM-biphasic" neurons). Here we compare the impact of 5-HT on the excitability of CPn and COM L5PNs experiencing variable excitatory drive produced by current injection (DC current or simulated synaptic current) or with exogenous glutamate. 5-HT delivered at resting membrane potentials, or paired with subthreshold depolarizing input, hyperpolarized CPn and COM-biphasic L5PNs and failed to promote AP generation in COM-excited L5PNs. Conversely, when paired with suprathreshold excitatory drive generating multiple APs, 5-HT suppressed AP output in CPn L5PNs, enhanced AP generation in COM-excited L5PNs, and generated variable responses in COM-biphasic L5PNs. While COM-excited neurons failed to respond to 5-HT in the presence of a 2A receptor antagonist, 32% of CPn neurons exhibited 2A-dependent excitation following blockade of 1A receptors. The presence of pharmacologically revealed 2A receptors in CPn L5PNs was correlated with the duration of 1A-mediated inhibition, yet biphasic excitatory responses to 5-HT were never observed, even when 5-HT was paired with strong excitatory drive. Our results suggest that 2A receptors selectively amplify the output of COM L5PNs experiencing suprathreshold excitatory drive, while shaping the duration of 1A-mediated inhibition in a subset of CPn L5PNs. Activity-dependent serotonergic excitation of COM L5PNs, combined with 1A-mediated inhibition of CPn and COM-biphasic L5PNs, may facilitate executive function by focusing network activity within cortical circuits subserving the most appropriate behavioral output.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.