Evidence map›Paper›PMID 25206296›Full record

SynthesisWorld journal of gastroenterology2014

S-1-based vs non-S-1-based chemotherapy in advanced gastric cancer: a meta-analysis.

Jian Yang, Yan Zhou, Ke Min, Qiang Yao, Chun-Ni Xu

Open access · bronzeAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 6 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 6 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Pooled it
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  5. The efficacy and safety of S-1-based regimens in the first-line treatment of advanced gastric cancer: a systematic review and meta-analysis.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2016
    Pooled it
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  7. Trial
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  12. Review
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  14. Phase I study of orally administered S-1 in combination with epirubicin and oxaliplatin in patients with advanced solid tumors and chemotherapy-naïve advanced or metastatic esophagogastric cancer.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2017
    Article
  15. Article
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  17. Emerging role of S-1 in gastric cancer.Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jian YangJian Yang, Yan Zhou, Ke Min, Qiang Yao, Chun-Ni Xu, Department of Oncology, Affiliated Yixing People's Hospital, Jiangsu University, Wuxi 214200, Jiangsu Province, China.
Yan ZhouJian Yang, Yan Zhou, Ke Min, Qiang Yao, Chun-Ni Xu, Department of Oncology, Affiliated Yixing People's Hospital, Jiangsu University, Wuxi 214200, Jiangsu Province, China.
Ke MinJian Yang, Yan Zhou, Ke Min, Qiang Yao, Chun-Ni Xu, Department of Oncology, Affiliated Yixing People's Hospital, Jiangsu University, Wuxi 214200, Jiangsu Province, China.
Qiang YaoJian Yang, Yan Zhou, Ke Min, Qiang Yao, Chun-Ni Xu, Department of Oncology, Affiliated Yixing People's Hospital, Jiangsu University, Wuxi 214200, Jiangsu Province, China.
Chun-Ni XuJian Yang, Yan Zhou, Ke Min, Qiang Yao, Chun-Ni Xu, Department of Oncology, Affiliated Yixing People's Hospital, Jiangsu University, Wuxi 214200, Jiangsu Province, China.
Jiangsu University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo assess the efficacy and tolerability of S-1-based vs non-S-1-based chemotherapy in advanced gastric cancer (AGC).

methodsWe extracted reported endpoints, including overall survival (OS), progression-free survival (PFS), time-to-treatment failure (TTF), objective response rate (ORR) and adverse effects, from randomized controlled trials identified in PubMed, the Cochrane library, Science Direct, EMBASE and American Society of Clinical Oncology meetings. Stata software was used to calculate the pooled values.

resultsSeven randomized controlled trials involving 2176 patients were included in this meta-analysis. Compared to non-S-1-based regimens, the use of S-1-based regimens were associated with an increase in ORR (RR = 1.300; 95%CI: 1.028-1.645); OS (HR = 0.89; 95%CI: 0.81-0.99; P = 0.025), TTF (HR = 0.83; 95%CI: 0.75-0.92; P = 0.000), and a lower risk of febrile neutropenia (RR = 0.225; P = 0.000) and stomatitis (RR = 0.230; P = 0.032). OS, PFS and TTF were prolonged, especially in the Asian population. In subgroup analysis, statistically significant increases in ORR (RR = 1.454; P = 0.029), OS (HR = 0.895; P = 0.041) and TTF (HR = 0.832; P = 0.000) were found when S-1-based chemotherapy was compared to 5-fluorouracil (5-FU)-based chemotherapy. The incidence of leukopenia (RR = 0.584; P = 0.002) and stomatitis (RR = 0.230; P = 0.032) was higher in the 5-FU-based arm. S-1-based regimens had no advantage in ORR, OS, PFS, TTF and grade 3 or 4 adverse events over capecitabine-based regimens.

conclusionS-1-based chemotherapy may be a good choice for AGC because of longer survival times, better tolerance and more convenient use.

Indexed as

Antimetabolites, AntineoplasticAntineoplastic Combined Chemotherapy ProtocolsChi-Square DistributionDisease-Free SurvivalDisease ProgressionDrug CombinationsHumansOxonic AcidRisk FactorsStomach NeoplasmsSurvival AnalysisTegafurTime FactorsTreatment OutcomeAntimetabolites, AntineoplasticDrug CombinationsOxonic AcidS 1 (combination)TegafurAdvanced gastric cancerChemotherapyFirst line treatmentMeta-analysisS-1

Identifiers

PMID25206296
PMCPMC4155382
OpenAlexW2138590299

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.