Observational studyWorld journal of gastroenterology2014
Low immediate postoperative platelet count is associated with hepatic insufficiency after hepatectomy.
Observational study in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The E-AHPBA-ESSO-Innsbruck consensus recommendations on peri- and postoperative management following liver resection.The British journal of surgery · 2025Guideline
- [Analysis of the efficacy and safety profile of the use of eltrombopag ethanolamine tablets in patients with cirrhotic thrombocytopenia].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026Article
- Spleen volume after stage-I associated liver partition and portal vein ligation for staged hepatectomy predicts future liver remnant.Langenbeck's archives of surgery · 2025Article
- Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics.Signal transduction and targeted therapy · 2025Review
- Article
- A Nomogram for Predicting Prognosis of AdvancedTropical medicine and infectious disease · 2023Article
- Issues to be considered to address the future liver remnant prior to major hepatectomy.Surgery today · 2021Review
- Till Death Do Us Part-The Multifaceted Role of Platelets in Liver Diseases.International journal of molecular sciences · 2021Review
- Acetylsalicylic acid (Aspirin®) and liver regeneration: experimental study in rats.Revista do Colegio Brasileiro de Cirurgioes · 2021Article
- Platelet and liver regeneration after liver surgery.Surgery today · 2020Review
- Clinical Implications of Thrombocytopenia for the Cirrhotic Patient.Hepatic medicine : evidence and research · 2020Review
- A novel model for predicting posthepatectomy liver failure in patients with hepatocellular carcinoma.PloS one · 2019Article
- Geriatric nutritional risk index predicts prognosis after hepatectomy in elderly patients with hepatitis B virus-related hepatocellular carcinoma.Scientific reports · 2018Article
- Platelets as Modulators of Liver Diseases.Seminars in thrombosis and hemostasis · 2018Review
- Preoperative Thrombocytopenia May Predict Poor Surgical Outcome after Extended Hepatectomy.Canadian journal of gastroenterology & hepatology · 2018Article
- Fibrosis-4 Model Influences Results of Patients with Hepatocellular Carcinoma Undergoing Hepatectomy.BioMed research international · 2018Article
- Predictive power of splenic thickness for post-hepatectomy liver failure in HBV-associated hepatocellular carcinoma patients.World journal of surgical oncology · 2017Article
- Liver transplantation versus surgical resection for HCC meeting the Milan criteria: A propensity score analysis.Medicine · 2016Article
- Evidence against a role for platelet-derived molecules in liver regeneration after partial hepatectomy in humans.Journal of clinical and translational research · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the relationship between low immediate postoperative platelet count and perioperative outcome after liver resection in patients with hepatocellular carcinoma (HCC).
methodsIn a cohort of 565 consecutive hepatitis B-related HCC patients who underwent major liver resection, the characteristics and clinical outcomes after liver resection were compared between patients with immediate postoperative platelet count < 100 × 10(9)/L and patients with platelet count ≥ 100 × 10(9)/L. Risk factors for postoperative hepatic insufficiency were evaluated by multivariate analysis.
resultsPatients with a low immediate postoperative platelet count (< 100 × 10(9)/L) had more grade III-V complications (20.5% vs 12.4%, P = 0.016), and higher rates of postoperative liver failure (6.8% vs 2.6%, P = 0.02), hepatic insufficiency (31.5% vs 21.2%, P < 0.001) and mortality (6.8% vs 0.5%, P < 0.001), compared to patients with a platelet count ≥ 100 × 10(9)/L. The alanine aminotransferase levels on postoperative days 3 and 5, and bilirubin on postoperative days 1, 3 and 5 were higher in patients with immediate postoperative low platelet count. Multivariate analysis revealed that immediate postoperative low platelet count, rather than preoperative low platelet count, was a significant independent risk factor for hepatic insufficiency.
conclusionA low immediate postoperative platelet count is an independent risk factor for hepatic insufficiency. Platelets can mediate liver regeneration in the cirrhotic liver.
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