Evidence map›Paper›PMID 25206284›Full record

ArticleWorld journal of gastroenterology2014

Molecular detection of monocyte chemotactic protein-1 polymorphism in spontaneous bacterial peritonitis patients.

Maysa Kamal Salama, Dina Sabry, Mohamed A S Al-Ghussein, Rasha Ahmed, Sayed AbdAllah, Fatma Mohamed Taha, Wael Fathy, Miriam Safwat Wadie, Mona Nabih, Amr Abul-Fotouh and 1 more

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Article in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Maysa Kamal SalamaMaysa Kamal Salama, Dina Sabry, Fatma Mohamed Taha, Miriam Safwat Wadie, Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Cairo11562, Egypt.
Dina SabryMaysa Kamal Salama, Dina Sabry, Fatma Mohamed Taha, Miriam Safwat Wadie, Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Cairo11562, Egypt.
Mohamed A S Al-GhusseinMaysa Kamal Salama, Dina Sabry, Fatma Mohamed Taha, Miriam Safwat Wadie, Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Cairo11562, Egypt.
Rasha AhmedMaysa Kamal Salama, Dina Sabry, Fatma Mohamed Taha, Miriam Safwat Wadie, Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Cairo11562, Egypt.
Sayed AbdAllahMaysa Kamal Salama, Dina Sabry, Fatma Mohamed Taha, Miriam Safwat Wadie, Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Cairo11562, Egypt.
Fatma Mohamed TahaMaysa Kamal Salama, Dina Sabry, Fatma Mohamed Taha, Miriam Safwat Wadie, Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Cairo11562, Egypt.
Wael FathyMaysa Kamal Salama, Dina Sabry, Fatma Mohamed Taha, Miriam Safwat Wadie, Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Cairo11562, Egypt.
Miriam Safwat WadieMaysa Kamal Salama, Dina Sabry, Fatma Mohamed Taha, Miriam Safwat Wadie, Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Cairo11562, Egypt.
Mona NabihMaysa Kamal Salama, Dina Sabry, Fatma Mohamed Taha, Miriam Safwat Wadie, Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Cairo11562, Egypt.
Amr Abul-FotouhMaysa Kamal Salama, Dina Sabry, Fatma Mohamed Taha, Miriam Safwat Wadie, Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Cairo11562, Egypt.
Tarneem DarwishMaysa Kamal Salama, Dina Sabry, Fatma Mohamed Taha, Miriam Safwat Wadie, Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Cairo11562, Egypt.
University of Sadat City · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the association of the functional monocyte chemotactic protein-1 (MCP-1) promoter polymorphism (A-2518G) with spontaneous bacterial peritonitis (SBP).

methodsFifty patients with post-hepatitis C liver cirrhosis and ascites were categorized into two groups; group I included 25 patients with SBP and group II included 25 patients free from SBP. In addition, a group of 20 healthy volunteers were included. We assessed the MCP-1 gene polymorphism and gene expression as well as interleukin (IL)-10 levels in both blood and ascitic fluid.

resultsA significant MCP-1 gene polymorphism was detected in groups I and II (P = 0.001 and 0.02 respectively). Group I was associated with a significantly higher frequency of AG genotype [control 8 (40%) vs SBP 19 (76.0%), P < 0.001], and group II was associated with a significantly higher frequency of GG genotype when compared to healthy volunteers [control 1 (5%) vs cirrhotic 16 (64%), P < 0.001]. Accordingly, the frequency of G allele was significantly higher in both groups (I and II) [control 10 (25%) vs SBP 27 (54%), P < 0.001 and vs cirrhotic 37 (74.0%), P < 0.001, respectively]. The total blood and ascetic fluid levels of IL-10 and MCP-1 gene expression were significantly higher in group I than in group II. Group I showed significant reductions in the levels of MCP-1 gene expression and IL-10 in the whole blood and ascetic fluid after therapy.

conclusionMCP-1 GG genotype and G allele may predispose HCV infected patients to a more progressive disease course, while AG genotype may increase the susceptibility to SBP. Patients carrying these genotypes should be under supervision to prevent or restrict further complications.

Indexed as

Polymorphism, GeneticAdultAscitesBacterial InfectionsBiomarkersCase-Control StudiesChemokine CCL2FemaleGene FrequencyGenetic Predisposition to DiseaseHepatitis CHumansInterleukin-10MaleMiddle AgedPeritonitisBiomarkersCCL2 protein, humanChemokine CCL2IL10 protein, humanInterleukin-10AscitesGene expressionGenotypeInterleukin-10Liver cirrhosisMonocyte chemotactic protein-1Spontaneous bacterial peritonitis

Identifiers

PMID25206284
PMCPMC4155370
OpenAlexW2000406661

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.