ArticleWorld journal of gastroenterology2014
Impacts of common factors of life style on serum liver enzymes.
Article in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Interpretation of Chemistry, Hematology and Coagulation Laboratory Results in Early-Phase Clinical Pharmacology Trials; a Retrospective Analysis Based on the Placebo Arm of Randomized-Controlled Trials.Clinical and translational science · 2026Article
- Effects of high ambient temperatures on liver function in an occupational population: Examining the mediation role of inflammatory cells and moderation role of age factors.Journal of exposure science & environmental epidemiology · 2026Article
- Indirect estimation of serum enzymes reference intervals in adults using the reflimR and refineR algorithms.Biochemia medica · 2026Article
- Determination of reference intervals for common liver function tests among healthy adults.Scientific reports · 2025Article
- Alcohol Drinking Patterns and Laboratory Indices of Health: Does Type of Alcohol Preferred Make a Difference?Nutrients · 2022Article
- Phenome-Wide Association Analysis Reveals Novel Links Between Genetically Determined Levels of Liver Enzymes and Disease Phenotypes.Phenomics (Cham, Switzerland) · 2022Article
- Reference intervals for common clinical chemistry parameters in healthy adults of Northeast Ethiopia.PloS one · 2022Article
- Data driven evaluation of healthy volunteer characteristics at screening for phase I clinical trials to inform on study design and optimize screening processes.Clinical and translational science · 2021Article
- Combined effects of lifestyle risk factors on fatty liver index.BMC gastroenterology · 2020Article
- Impacts of unfavourable lifestyle factors on biomarkers of liver function, inflammation and lipid status.PloS one · 2019Article
- Laboratory blood test results beyond normal ranges could not be attributed to healthy aging.Medicine · 2018Observational
- Personality traits and facets linked with self-reported alcohol consumption and biomarkers of liver health.Addictive behaviors · 2018Article
- Ideal cardiovascular health and liver enzyme levels in European adolescents; the HELENA study.Journal of physiology and biochemistry · 2017Article
- Where should the safe limits of alcohol consumption stand in light of liver enzyme abnormalities in alcohol consumers?PloS one · 2017Article
- Neglected features of lifestyle: Their relevance in non-alcoholic fatty liver disease.World journal of hepatology · 2016Article
- Biomarker-Based Approaches for Assessing Alcohol Use Disorders.International journal of environmental research and public health · 2016Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the impacts of gender, age and factors of life style (alcohol, overweight, coffee and smoking) on serum liver enzymes.
methodsSerum alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) were measured from 6269 apparently healthy individuals (2851 men, 3418 women, mean age 45 ± 12 years, range 25-74 years) in a national cross-sectional health survey. All subjects underwent detailed clinical examinations and interviews including the amount and pattern of alcohol use, coffee consumption and smoking habits.
resultsIn this population with a mean ± SD alcohol consumption of 65 ± 105 g/wk and body mass index (BMI) of 26.1 ± 4.3 kg/m(2), both ALT and GGT were significantly influenced by alcohol use (P < 0.001) and BMI (P < 0.001), whereas smoking increased only GGT (P < 0.001). A significant effect of age on ALT was seen in men (P < 0.001) whereas not in women. Significant two-factor interactions of alcohol use in men were observed with age (ALT: P < 0.01; GGT: P < 0.001) and BMI (GGT: P < 0.05). For ALT, a significant interaction also occurred between BMI and age (P < 0.005). In contrast, women showed significant interactions of alcohol use with BMI (GGT: P < 0.05), smoking (GGT: P < 0.001), and coffee consumption (GGT: P < 0.001).
conclusionLife-style associated changes in liver enzymes may reflect health risks, which should be considered in the definition of normal limits for liver enzymes.
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