ArticleAnnals of neurosciences2014
Effects of chronic administration of gabapentin and carbamazepine on the histomorphology of the hippocampus and striatum.
Article in Annals of neurosciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Assessment of Trigeminal Nerve Root Demyelination in Patients with Primary Trigeminal Neuralgia Using Macromolecular Proton Fraction Imaging.AJNR. American journal of neuroradiology · 2025Article
- Gabapentin-Induced Sub-Chronic Neurotoxicity in Rats and the Protective Role of Alpha-Tocopherol.Turk patoloji dergisi · 2025Article
- Neuroprotective Properties of Antiepileptics: What are the Implications for Psychiatric Disorders?Current medicinal chemistry · 2024Review
- Gabapentin-Friend or foe?Pain practice : the official journal of World Institute of Pain · 2023Review
- Leveraging high-resolution 7-tesla MRI to derive quantitative metrics for the trigeminal nerve and subnuclei of limbic structures in trigeminal neuralgia.The journal of headache and pain · 2021Article
- Selective hippocampal subfield volume reductions in classic trigeminal neuralgia.NeuroImage. Clinical · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAntiepileptic drugs used to avert epileptic seizures necessitate prolonged duration for improved efficacy and could induce some side effects. PURPOSE: The present study investigated the effect of chronic administration of two common antiepileptic drugs - gabapentin and carbamazepine, on the histomorphology of the hippocampus and striatum in adult rats.
methods25 adult male Wistar rats were grouped randomly into 5 groups. 3 groups were administered either therapeutic doses of gabapentin (16 mg/kg) or carbamazepine (20 mg/kg) or sub-therapeutic dose of gabapentin plus carbamazepine (8 + 10 mg/kg). To confirm anticonvulsant effects, these animals were kindled for seizures at sub-maximal electroshock. Appropriate negative and positive controls were given normal saline. At the end of treatment, brain tissues were obtained and processed for histological procedures.
resultsThe study confirm significant decrease (P<0.001) in convulsion parameters tonic flexion, tonic extension and clonic convulsion, between drug treated groups and electroshock control. Histological studies revealed significant increase (p<0.001) in neurons showing features of degeneration in the hippocampus, for drug treated groups as compared to normal and electroshock control. Also, drug treatment reduced nissl activity in both hippocampus and striatum.
conclusionChronic administration of gabapentin and carbamazepine may cause increase in neurodegenerative changes in the adult brain.
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