Evidence map›Paper›PMID 25205808›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2014

PreImplantation factor promotes neuroprotection by targeting microRNA let-7.

Martin Mueller, Jichun Zhou, Lihua Yang, Yuan Gao, Fuju Wu, Andreina Schoeberlein, Daniel Surbek, Eytan R Barnea, Michael Paidas, Yingqun Huang

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 73 citations in OpenAlex.

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  7. Endometrial Microbiota and Immune Tolerance in Pregnancy.International journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 3 countries.

Martin MuellerDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510; Department of Obstetrics and Gynecology, University Hospital, 3010 Bern, Switzerland;
Jichun ZhouDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510; Department of Surgical Oncology, Affiliated Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, People's Republic of China;
Lihua YangDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510; Department of Obstetrics and Gynecology, Tangshan Gongren Hospital, Tangshan, Hebei 063000, People's Republic of China;
Yuan GaoDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510; Department of Gynecology and Obstetrics, Chinese PLA General Hospital, Beijing 100853, People's Republic of China;
Fuju WuDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510; Department of Obstetrics and Gynecology, Jilin University, Changchun, Jilin 130021, People's Republic of China;
Andreina SchoeberleinDepartment of Clinical Research, University of Bern, 3012 Bern, Switzerland;
Daniel SurbekDepartment of Obstetrics and Gynecology, University Hospital, 3010 Bern, Switzerland; Department of Clinical Research, University of Bern, 3012 Bern, Switzerland;
Eytan R BarneaSociety for the Investigation of Early Pregnancy, Cherry Hill, NJ 08003; BioIncept, LLC, Cherry Hill, NJ 08003; and.
Michael PaidasDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510; Women and Children's Center for Blood Disorders, Yale University School of Medicine, New Haven, CT 06510 michael.paidas@yale.edu yingqun.huang@yale.edu.
Yingqun HuangDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510; michael.paidas@yale.edu yingqun.huang@yale.edu.
Yale University · USChinese PLA General Hospital · CNJilin University · CNSir Run Run Shaw Hospital · CNSociety for the Investigation of Early Pregnancy · USUniversity Hospital of Bern · CHUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dysfunction and loss of neurons are the major characteristics of CNS disorders that include stroke, multiple sclerosis, and Alzheimer's disease. Activation of the Toll-like receptor 7 by extracellular microRNA let-7, a highly expressed microRNA in the CNS, induces neuronal cell death. Let-7 released from injured neurons and immune cells acts on neighboring cells, exacerbating CNS damage. Here we show that a synthetic peptide analogous to the mammalian PreImplantation factor (PIF) secreted by developing embryos and which is present in the maternal circulation during pregnancy inhibits the biogenesis of let-7 in both neuronal and immune cells of the mouse. The synthetic peptide, sPIF, destabilizes KH-type splicing regulatory protein (KSRP), a key microRNA-processing protein, in a Toll-like receptor 4 (TLR4)-dependent manner, leading to decreased production of let-7. Furthermore, s.c. administration of sPIF into neonatal rats following hypoxic-ischemic brain injury robustly rescued cortical volume and number of neurons and decreased the detrimental glial response, as is consistent with diminished levels of KSRP and let-7 in sPIF-treated brains. Our results reveal a previously unexpected mechanism of action of PIF and underscore the potential clinical utility of sPIF in treating hypoxic-ischemic brain damage. The newly identified PIF/TLR4/KSRP/let-7 regulatory axis also may operate during embryo implantation and development.

Indexed as

AnimalsBlastocystBrain IschemiaEmbryo ImplantationFemaleMiceMicroRNAsPeptidesPregnancyRatsRats, WistarRNA-Binding ProteinsToll-Like Receptor 4Trans-ActivatorsKhsrp protein, mouseMicroRNAsmirnlet7 microRNA, mouseMIRNLET7 microRNA, ratPeptidespreimplantation factor, mouseRNA-Binding ProteinsTlr4 protein, mouseTlr4 protein, ratToll-Like Receptor 4Trans-Activators

Identifiers

PMID25205808
PMCPMC4183321
OpenAlexW2101458866

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.