ArticleDevelopmental neurobiology2015
Effects of COX inhibition and LPS on formalin induced pain in the infant rat.
Article in Developmental neurobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Sexually dimorphic developmental changes in rat spinal cord pain pathways following neonatal inflammation.Physiological reports · 2025Article
- Early life inflammation is associated with spinal cord excitability and nociceptive sensitivity in human infants.Nature communications · 2022Article
- Effect of Parecoxib Sodium on Myocardial Ischemia-Reperfusion Injury Rats.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- Local injury and systemic infection in infants alter later nociception and pain affect during early life and adulthood.Brain, behavior, & immunity - health · 2020Article
- Neuroimmune modulation of pain across the developmental spectrum.Current opinion in behavioral sciences · 2019Article
- Essential role of endogenous calcitonin gene-related peptide in pain-associated plasticity in the central amygdala.The European journal of neuroscience · 2017Article
- Lifetime Modulation of the Pain SystemFrontiers in immunology · 2017Review
- Early life programming of pain: focus on neuroimmune to endocrine communication.Journal of translational medicine · 2016Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
In the adult, immune and neural processes jointly modulate pain. During development, both are in transition and little is known about the role that the immune system plays in pain processing in infants and children. The objective of this study was to determine if inhibition or augmentation of the immune system would alter pain processing in the infant rat, as it does in the adult. In Experiment 1, rat pups aged 3, 10, or 21 (PN3, PN10, and PN21) days of age were pretreated with NS398 (selective cyclooxygenase (COX)-2 inhibitor) or SC560 (selective COX-1 inhibitor) and tested in the intraplantar formalin test to assess effects of COX inhibition on nociception. Neither drug had an effect on the behavioral response at PN3 or PN10 pups but both drugs attenuated nociceptive scores in PN21 pups. cFos expression in the spinal cord likewise was reduced only at PN21. In Experiment 2, pups were injected with lipopolysaccharide (LPS) prior to the formalin test at PN3 or PN21. LPS increased the nociceptive response more robustly at PN21 than at PN3, while increasing cytokine mRNA equally at both ages. The augmentation of pain responding at PN21 was largely during the late stages of the formalin test, as reported in the adult. These data support previous findings demonstrating late maturing immune modulation of nociceptive behaviors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.