ArticleScientific reports2014
Live cell imaging of membrane/cytoskeleton interactions and membrane topology.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Metabolomic analysis of bone-derived exosomes in osteonecrosis of the femoral head based on UPLC-MS/MS.Metabolomics : Official journal of the Metabolomic Society · 2023Article
- Article
- Quantitative FRET Microscopy Reveals a Crucial Role of Cytoskeleton in Promoting PI(4,5)PInternational journal of molecular sciences · 2021Article
- Membrane signalosome: where biophysics meets systems biology.Current opinion in systems biology · 2021Article
- Structure and Lateral Organization of Phosphatidylinositol 4,5-bisphosphate.Molecules (Basel, Switzerland) · 2020Review
- Divalent cations bind to phosphoinositides to induce ion and isomer specific propensities for nano-cluster initiation in bilayer membranes.Royal Society open science · 2020Article
- Dynamic Manipulation of Cell Membrane Curvature by Light-Driven Reshaping of Azopolymer.Nano letters · 2020Article
- Hydrogel systems and their role in neural tissue engineering.Journal of the Royal Society, Interface · 2020Review
- Controlled Cellular Delivery of Amphiphilic Cargo by Redox-Responsive Nanocontainers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- SALM1 controls synapse development by promoting F-actin/PIP2-dependent Neurexin clustering.The EMBO journal · 2019Article
- Lateral distribution of phosphatidylinositol 4,5-bisphosphate in membranes regulates formin- and ARP2/3-mediated actin nucleation.The Journal of biological chemistry · 2019Article
- Global urinary metabolic profiling of the osteonecrosis of the femoral head based on UPLC-QTOF/MS.Metabolomics : Official journal of the Metabolomic Society · 2019Article
- A phosphatidylinositol 4,5-bisphosphate redistribution-based sensing mechanism initiates a phagocytosis programing.Nature communications · 2018Article
- Application of polymersomes engineered to target p32 protein for detection of small breast tumors in mice.Oncotarget · 2018Article
- Lipid signaling affects primary fibroblast collective migration and anchorage in response to stiffness and microtopography.Journal of cellular physiology · 2018Article
- GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells.eLife · 2018Article
- iRGD peptide conjugation potentiates intraperitoneal tumor delivery of paclitaxel with polymersomes.Biomaterials · 2016Article
- Paclitaxel-Loaded Polymersomes for Enhanced Intraperitoneal Chemotherapy.Molecular cancer therapeutics · 2016Article
- Evidence that phospholipase C is involved in the antitumour action of NSC768313, a new thieno[2,3-b]pyridine derivative.Cancer cell international · 2016Article
- Lipid binding by the N-terminal motif mediates plasma membrane localization of Bordetella effector protein BteA.The Journal of biological chemistryArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We elucidate the interaction between actin and specific membrane components, using real time live cell imaging, by delivering probes that enable access to components, that cannot be accessed genetically. We initially investigated the close interplay between Phosphatidylinositol 4,5-bisphosphate (PIP2) and the F-actin network. We show that, during the early stage of cell adhesion, PIP2 forms domains within the filopodia membrane. We studied these domains alongside cell spreading and observed that these very closely follow the actin tread-milling. We show that this mechanism is associated with an active transport of PIP2 rich organelles from the cell perinuclear area to the edge, along actin fibers. Finally, mapping other phospholipids and membrane components we observed that the PIP2 domains formation is correlated with sphingosine and cholesterol rafts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.