ArticleBMC evolutionary biology2014
Analysis of hypoxia-inducible factor alpha polyploidization reveals adaptation to Tibetan Plateau in the evolution of schizothoracine fish.
Article in BMC evolutionary biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 66 citations in OpenAlex.
- Climate Change and Hydropower Impacts on Habitat Suitability of Endangered Schizothoracinae Fishes in the Qinghai-Xizang Plateau.Ecology and evolution · 2026Article
- Haplotype-resolved chromosome-level genome assembly of Schizothorax davidi.Scientific data · 2026Article
- Schizothoracinae in Plateau River Networks: Drainage History, Polyploid Genome Evolution, Multi-Omics Evidence Chains, and Conservation Units.Animals : an open access journal from MDPI · 2026Review
- Comparative study of fish adaptation at cellular and genetic levels across eco-sensitive zones with contrasting oxygen and temperature regimes.Scientific reports · 2025Article
- Dispersal Limitation Dominates Riverine Fish Communities in the Areas of the Water Diversion Project in the Western Sichuan Plateau, China.Animals : an open access journal from MDPI · 2025Article
- Evolution of Key Oxygen-Sensing Genes Is Associated with Hypoxia Tolerance in Fishes.Genome biology and evolution · 2024Article
- Post-Subfunctionalization Functions of HIF-1αA and HIF-1αB in Cyprinid Fish: Fine-Tuning Mitophagy and Apoptosis Regulation Under Hypoxic Stress.Journal of molecular evolution · 2023Article
- Functional exploration of SNP mutations in HIF2αb gene correlated with hypoxia tolerance in blunt snout bream (Megalobrama amblycephala).Fish physiology and biochemistry · 2023Article
- Genomic analysis of hypoxia inducible factor alpha in ray-finned fishes reveals missing Ohnologs and evidence of widespread positive selection.Scientific reports · 2022Article
- Insights Into miRNA-mRNA Regulatory Mechanisms of Cold Adaptation inFrontiers in genetics · 2022Article
- Parallel introgression, not recurrent emergence, explains apparent elevational ecotypes of polyploid Himalayan snowtrout.Royal Society open science · 2021Article
- Genomic Signature of Shifts in Selection and Alkaline Adaptation in Highland Fish.Genome biology and evolution · 2021Article
- Specific cyprinid HIF isoforms contribute to cellular mitochondrial regulation.Scientific reports · 2020Article
- Hypoxia-inducible factor 1α from a high-altitude fish enhances cytoprotection and elevates nitric oxide production in hypoxic environment.Fish physiology and biochemistry · 2020Article
- Disentangling the interplay of positive and negative selection forces that shaped mitochondrial genomes ofRoyal Society open science · 2020Article
- Transcriptome-Wide Patterns of the Genetic and Expression Variations in Two Sympatric Schizothoracine Fishes in a Tibetan Plateau Glacier Lake.Genome biology and evolution · 2020Article
- Analysis of Multiplicity of Hypoxia-Inducible Factors in the Evolution ofFrontiers in genetics · 2020Article
- Experimental study of hypoxia-induced changes in gene expression in an Asian pika, Ochotona dauurica.PloS one · 2020Article
- Evolution of metazoan oxygen-sensing involved a conserved divergence of VHL affinity for HIF1α and HIF2α.Nature communications · 2019Article
- Molecular evolution of myoglobin in the Tibetan Plateau endemic schizothoracine fish (Cyprinidae, Teleostei) and tissue-specific expression changes under hypoxia.Fish physiology and biochemistry · 2018Article
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5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypoxia-inducible factor (HIF) is a master regulator that mediates major changes in gene expression under hypoxic conditions. Though HIF family has been identified in many organisms, little is known about this family in schizothoracine fish.
resultsDuplicated hif-α (hif-1αA, hif-1αB, hif-2αA, and hif-2αB) genes were identified in schizothoracine fish. All the deduced HIF-α proteins contain the main domains (bHLH-PAS, ODDD, and TAD), also found in humans. Evidence suggests a Cyprinidae-specific deletion, specifically, a conserved proline hydroxylation motif LxxLAP, in the NODD domain of schizothoracine fish HIF-1αA. In addition, a schizothoracine-specific mutation was observed in the CODD domain of the specialized and highly specialized schizothoracine fish HIF-1αB, which is the proline hydroxylation motif mutated into PxxLAP. Standard and stochastic branch-site codon model analysis indicated that only HIF-1αB has undergone positive selection, which may have led to changes in function. To confirm this hypothesis, HIF-αs tagged with Myc were transfected into HEK 293 T cells. Each HIF-1αB was found to significantly upregulate luciferase activity under normoxic and hypoxic conditions, which indicated that the HIF-1αB protein was more stable than other HIF-αs.
conclusionsAll deduced HIF-α proteins of schizothoracine fish contain important domains, like their mammalian counterparts, and each HIF-α is shorter than that of human. Our experiments reveal that teleost-specific duplicated hif-α genes played different roles under hypoxic conditions, and HIF-1αB may be the most important regulator in the adaptation of schizothoracine fish to the environment of the Tibetan Plateau.
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