ReviewClinical reviews in allergy & immunology2014
Alternaria alternata and its allergens: a comprehensive review.
Review in Clinical reviews in allergy & immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 114 citations in OpenAlex.
- The Vacuolar CaMolecular plant pathology · 2026Article
- A Bibliographic Review of Airborne Fungal Allergens from Dominant and Undercharacterized Genera.Medicina (Kaunas, Lithuania) · 2026Review
- An Overview of theJournal of fungi (Basel, Switzerland) · 2026Review
- Validity of anJournal of asthma and allergy · 2026Article
- Article
- Fungi as an emerging waterborne health concern: impact of treated wastewater dischargeEnvironmental science. Processes & impacts · 2025Article
- Article
- What are the 100 most cited fungal genera?Studies in mycology · 2024Article
- Fungal Sensitization and Human Allergic Disease.Current allergy and asthma reports · 2024Review
- In silico approaches for the identification of potential allergens among hypothetical proteins from Alternaria alternata and its functional annotation.Scientific reports · 2024Article
- Article
- Screening of Anti-Inflammatory Activity and Metabolomics Analysis of Endophytic Fungal Extracts; Identification and Characterization of Perylenequinones and Terpenoids from the Interesting Active Alternaria Endophyte.Molecules (Basel, Switzerland) · 2023Article
- Article
- Going over Fungal Allergy:Journal of fungi (Basel, Switzerland) · 2023Review
- Allergen-induced DNA release by the airway epithelium amplifies type 2 immunity.The Journal of allergy and clinical immunology · 2023Article
- New Dibenzo-Marine drugs · 2022Article
- Activity of Aqueous Extracts from Native Plants of the Yucatan Peninsula against Fungal Pathogens of Tomato In Vitro and fromPlants (Basel, Switzerland) · 2022Article
- Transcontinental Dispersal of Nonendemic Fungal Pathogens through Wooden Handicraft Imports.mBio · 2022Article
- Endophytic Fungi Associated with Coffee Leaves in China Exhibited In Vitro Antagonism against Fungal and Bacterial Pathogens.Journal of fungi (Basel, Switzerland) · 2022Article
- Fungal Allergen and Mold Allergy Diagnosis: Role and Relevance ofJournal of fungi (Basel, Switzerland) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alternaria alternata is mainly an outdoor fungus whose spores disseminate in warm, dry air, so in temperate climates, their count peaks in the summers. Alternaria may also be found in damp, insufficiently ventilated houses, where its allergenic properties cocreate the sick building syndrome. Mold-induced respiratory allergies and research on Alternaria both have a lengthy history: the first was described as early as 1698 and the second dates back to 1817. However, the two were only linked in 1930 when Alternaria spores were found to cause allergic asthma. The allergenic extracts from Alternaria hyphae and spores still remain in use but are variable and insufficiently standardized as they are often a random mixture of allergenic ingredients and coincidental impurities. In contrast, contemporary biochemistry and molecular biology make it possible to obtain pure allergen molecules. To date, 16 allergens of A. alternata have been isolated, many of which are enzymes: Alt a 4 (disulfide isomerase), Alt a 6 (enolase), Alt a 8 (mannitol dehydrogenase), Alt a 10 (alcohol dehydrogenase), Alt a 13 (glutathione-S-transferase), and Alt a MnSOD (Mn superoxide dismutase). Others have structural and regulatory functions: Alt a 5 and Alt a 12 comprise the structure of large ribosomal subunits and mediate translation, Alt a 3 is a molecular chaperone, Alt a 7 regulates transcription, Alt a NTF2 facilitates protein import into the nucleus, and Alt a TCTP acts like a cytokine. The function of four allergenic proteins, Alt a 1, Alt a 2, Alt a 9, and Alt a 70 kDa, remains unknown.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.