Trial reportEuropean journal of clinical nutrition2015
Probiotics and vitamin C for the prevention of respiratory tract infections in children attending preschool: a randomised controlled pilot study.
Trial report in European journal of clinical nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Effects of probiotics on salivary cytokines and immunoglobulines: a systematic review and meta-analysis on clinical trials.Scientific reports · 2020Pooled it
- Probiotics for preventing acute otitis media in children.The Cochrane database of systematic reviews · 2019Pooled it
- Efficacy of vitamin C for the prevention and treatment of upper respiratory tract infection. A meta-analysis in children.European journal of clinical pharmacology · 2019Pooled it
- The Effects of Increasing Fruit and Vegetable Intake in Children with Asthma on the Modulation of Innate Immune Responses.Nutrients · 2022Trial
- Alterations of intestinal flora and the effects of probiotics in children with recurrent respiratory tract infection.World journal of pediatrics : WJP · 2019Trial
- Trial
- Role of short-term use of L. acidophilus DDS-1 and B. lactis UABLA-12 in acute respiratory infections in children: a randomized controlled trial.European journal of clinical nutrition · 2016Trial
- Enhanced formulation of precision probiotics through active machine learning.Biology methods & protocols · 2026Article
- The association between serum vitamin C levels and respiratory infections in children and adolescents.Frontiers in nutrition · 2025Article
- The relationship between serum vitamin C levels and high-sensitivity C-reactive protein in children.Scientific reports · 2024Article
- The impact of probiotics and vitamin C on the prevention of upper respiratory tract symptoms in two preschool children cohorts.Nutrition research and practice · 2024Article
- Circulating micronutrient levels and respiratory infection susceptibility and severity: a bidirectional Mendelian randomization analysis.Frontiers in nutrition · 2024Article
- Role of multi-strain probiotics in preventing severity and frequency of recurrent respiratory tract infections in children.BMC pediatrics · 2023Article
- Potential probiotics for regulation of the gut-lung axis to prevent or alleviate influenza in vulnerable populations.Journal of traditional and complementary medicine · 2023Review
- The Role of Vitamin C in Human Immunity and Its Treatment Potential Against COVID-19: A Review Article.Cureus · 2023Review
- The synergistic effect ofFrontiers in cellular and infection microbiology · 2023Article
- Nutritional risk factors for SARS-CoV-2 infection: a prospective study within the NutriNet-Santé cohort.BMC medicine · 2021Article
- Systematic Network and Meta-analysis on the Antiviral Mechanisms of Probiotics: A Preventive and Treatment Strategy to Mitigate SARS-CoV-2 Infection.Probiotics and antimicrobial proteins · 2021Article
- Nutritional status, diet and viral respiratory infections: perspectives for severe acute respiratory syndrome coronavirus 2.The British journal of nutrition · 2021Review
- Probiotic Effects against Virus Infections: New Weapons for an Old War.Foods (Basel, Switzerland) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis pilot study investigates the efficacy of a probiotic consortium (Lab4) in combination with vitamin C on the prevention of respiratory tract infections in children attending preschool facilities. SUBJECTS/
methodsIn a double-blind, randomised, placebo-controlled pilot study with children aged 3-6 years, 57 received 1.25 × 10(10) colony-forming units of Lactobacillus acidophilus CUL21 (NCIMB 30156), Lactobacillus acidophilus CUL60 (NCIMB 30157), Bifidobacterium bifidum CUL20 (NCIMB 30153) and Bifidobacterium animalis subsp. lactis CUL34 (NCIMB 30172) plus 50 mg vitamin C or a placebo daily for 6 months.
resultsSignificant reductions in the incidence rate of upper respiratory tract infection (URTI; 33%, P=0.002), the number of days with URTI symptoms (mean difference: -21.0, 95% confidence interval (CI):-35.9, -6.0, P=0.006) and the incidence rate of absence from preschool (30%, P=0.007) were observed in the active group compared with the placebo. The number of days of use of antibiotics, painkillers, cough medicine or nasal sprays was lower in the active group and reached significance for use of cough medicine (mean difference: -6.6, 95% CI: -12.9, -0.3, P=0.040). No significant differences were observed in the incidence rate ratio or duration of lower respiratory tract infection or in the levels of plasma cytokines, salivary immunoglobulin A or urinary metabolites.
conclusionsSupplementation with a probiotic/vitamin C combination may be beneficial in the prevention and management of URTIs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.