ArticleBMC developmental biology2014
A self-avoidance mechanism in patterning of the urinary collecting duct tree.
Article in BMC developmental biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- TGFβ determines epithelial tissue spacing by regulating mesenchymal condensation.Cell reports · 2026Article
- TGFβ determines epithelial tissue spacing by regulating mesenchymal condensation.bioRxiv : the preprint server for biology · 2026Article
- Engineering kidney developmental trajectory using culture boundary conditions.Nature communications · 2025Article
- Jamming of nephron-forming niches in the developing mouse kidney creates cyclical mechanical stresses.Nature materials · 2024Article
- TheProceedings of the National Academy of Sciences of the United States of America · 2024Article
- The developing murine kidney actively negotiates geometric packing conflicts to avoid defects.Developmental cell · 2023Article
- Theory of branching morphogenesis by local interactions and global guidance.Nature communications · 2021Article
- Connection of ES Cell-derived Collecting Ducts and Ureter-like Structures to Host Kidneys in Culture.Organogenesis · 2021Article
- Local accumulation of extracellular matrix regulates global morphogenetic patterning in the developing mammary gland.Current biology : CB · 2021Article
- Organ-Specific Branching Morphogenesis.Frontiers in cell and developmental biology · 2021Review
- Autocrine inhibition of cell motility can drive epithelial branching morphogenesis in the absence of growth.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- In developing mouse kidneys, orientation of loop of Henle growth is adaptive and guided by long-range cues from medullary collecting ducts.Journal of anatomy · 2019Article
- Image-based modeling of kidney branching morphogenesis reveals GDNF-RET based Turing-type mechanism and pattern-modulating WNT11 feedback.Nature communications · 2019Article
- Statistical theory of branching morphogenesis.Development, growth & differentiation · 2018Review
- Bayesian inference of agent-based models: a tool for studying kidney branching morphogenesis.Journal of mathematical biology · 2018Article
- Adaptive self-organization in the embryo: its importance to adult anatomy and to tissue engineering.Journal of anatomy · 2018Review
- Sebinger Culture: A System Optimized for Morphological Maturation and Imaging of Cultured Mouse Metanephric Primordia.Bio-protocol · 2018Article
- Article
- Symmetry-breaking in branching epithelia: cells on micro-patterns under flow challenge the hypothesis of positive feedback by a secreted autocrine inhibitor of motility.Journal of anatomy · 2017Article
- Development of the Mammalian Kidney.Current topics in developmental biology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundGlandular organs require the development of a correctly patterned epithelial tree. These arise by iterative branching: early branches have a stereotyped anatomy, while subsequent branching is more flexible, branches spacing out to avoid entanglement. Previous studies have suggested different genetic programs are responsible for these two classes of branches.
resultsHere, working with the urinary collecting duct tree of mouse kidneys, we show that the transition from the initial, stereotyped, wide branching to narrower later branching is independent from previous branching events but depends instead on the proximity of other branch tips. A simple computer model suggests that a repelling molecule secreted by branches can in principle generate a well-spaced tree that switches automatically from wide initial branch angles to narrower subsequent ones, and that co-cultured trees would distort their normal shapes rather than colliding. We confirm this collision-avoidance experimentally using organ cultures, and identify BMP7 as the repelling molecule.
conclusionsWe propose that self-avoidance, an intrinsically error-correcting mechanism, may be an important patterning mechanism in collecting duct branching, operating along with already-known mesenchyme-derived paracrine factors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.