ArticleNeuroImage2014
Alterations of hippocampal projections in adult macaques with neonatal hippocampal lesions: a Diffusion Tensor Imaging study.
Article in NeuroImage, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Diencephalic integrity explains aspects of hippocampal amnesia.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Interaction and functional specialization across a distributed neural circuit for flexible task control in macaques.Nature communications · 2026Article
- Review
- Review
- Acoustic startle and prepulse inhibition deficits in adult monkeys with neonatal lesions of the hippocampus, amygdala and orbital frontal cortex.Behavioural brain research · 2023Article
- Differential responses toward conditioned and unconditioned stimuli, but decreased hypothalamic-pituitary-adrenal axis responsiveness in neonatal hippocampal lesioned monkeys.Developmental cognitive neuroscience · 2022Article
- Combining brain perturbation and neuroimaging in non-human primates.NeuroImage · 2021Review
- Altered hippocampal-prefrontal functional network integrity in adult macaque monkeys with neonatal hippocampal lesions.NeuroImage · 2021Article
- Corticocortical and Thalamocortical Changes in Functional Connectivity and White Matter Structural Integrity after Reward-Guided Learning of Visuospatial Discriminations in Rhesus Monkeys.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Lifespan Trajectories of White Matter Changes in Rhesus Monkeys.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Article
- Whole body MRI of the non-human primate using a clinical 3T scanner: initial experiences.Quantitative imaging in medicine and surgery · 2017Article
- Increased anxiety-like behaviors, but blunted cortisol stress response after neonatal hippocampal lesions in monkeys.Psychoneuroendocrinology · 2017Article
- The effects of hippocampal lesions on MRI measures of structural and functional connectivity.Hippocampus · 2016Article
- Decreased functional connectivity in dorsolateral prefrontal cortical networks in adult macaques with neonatal hippocampal lesions: Relations to visual working memory deficits.Neurobiology of learning and memory · 2016Article
- Molecular substrates of schizophrenia: homeostatic signaling to connectivity.Molecular psychiatry · 2016Review
- Off to a Good Start: The Early Development of the Neural Substrates Underlying Visual Working Memory.Frontiers in systems neuroscience · 2016Review
- Transcallosal connectivity changes from infancy to late adulthood: an ex vivo diffusion spectrum imaging study of macaque brains.Brain connectivity · 2015Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Neuropsychological and brain imaging studies have demonstrated persistent deficits in memory functions and structural changes after neonatal neurotoxic hippocampal lesion in monkeys. However, the relevant microstructural changes in the white matter of affected brain regions following this early insult remain unknown. This study assessed white matter integrity in the main hippocampal projections of adult macaque monkeys with neonatal hippocampal lesions, using diffusion tensor imaging (DTI). Data analysis was performed using tract-based spatial statistics (TBSS) and compared with volume of interest statistics. Alterations of fractional anisotropy (FA) and diffusivity indices were observed in fornix, temporal stem, ventromedial prefrontal cortex and optical radiations. To further validate the lesion effects on the prefrontal cortex, probabilistic diffusion tractography was used to examine the integrity of the fiber connections between hippocampus and ventromedial prefrontal cortex, and alterations were found in these connections. In addition, increased radial diffusivity in the left ventromedial prefrontal cortex correlated negatively with the severity of deficits in working memory in the same monkeys. The findings revealed microstructural changes due to neonatal hippocampal lesion, and confirmed that neonatal neurotoxic hippocampal lesions resulted in significant and enduring functional alterations in the hippocampal projection system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.