Evidence map›Paper›PMID 25204453›Full record

Trial reportJournal of feline medicine and surgery2015

Effect of ciclosporin and methylprednisolone acetate on cats previously infected with feline herpesvirus 1.

Michael R Lappin, Linda M Roycroft

Open access · bronzeAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of feline medicine and surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Michael R LappinDepartment of Clinical Sciences, Colorado State University, Fort Collins, USA mlappin@colostate.edu.
Linda M RoycroftNovartis Animal Health US, Greensboro, USA.
Colorado State University · USNovant Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Feline herpesvirus 1 (FHV-1) is a common ocular and respiratory pathogen of cats that can be associated with recurrent clinical signs of disease. Ciclosporin (cyclosporine) is commonly administered per os (PO) for the treatment of a number of inflammatory diseases in cats. A number of client-owned cats administered ciclosporin (cyclosporine) A (CsA) PO to block renal transplant rejection have developed clinical signs of upper respiratory tract disease that may have been from activated FHV-1. In this study, cats experimentally inoculated with FHV-1 several months previously were administered methylprednisolone acetate intramuscularly, CsA PO or a placebo PO. While clinical signs of activated FHV-1 occurred in some cats, disease was mild and self-limited in most cats. There was no vomiting, diarrhea, inappetence, weight loss, polydipsia, polyuria or polyphagia recognized.

Indexed as

Administration, OralAnimalsAnti-Inflammatory AgentsCat DiseasesCatsCyclosporineDose-Response Relationship, DrugFemaleHerpesviridaeHerpesviridae InfectionsMethylprednisoloneMethylprednisolone AcetatePregnancyRespiratory Tract InfectionsSpecific Pathogen-Free OrganismsAnti-Inflammatory AgentsCyclosporineMethylprednisoloneMethylprednisolone Acetate

Identifiers

PMID25204453
PMCPMC11104156
OpenAlexW2132165895

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.