ArticleThe Analyst2014
Modification of microfluidic paper-based devices with silica nanoparticles.
Article in The Analyst, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 176 citations in OpenAlex.
- Development of colorimetric and machine learning based accurate glucose detection platform for point of care applications.Scientific reports · 2026Article
- Paper-Based Microfluidic Chips for At-Home Point-of-Care Nucleic Acid Testing: Applications and Challenges.Diagnostics (Basel, Switzerland) · 2026Review
- Challenges in the development of microfluidic paper-based analytical devices (μPADs).Mikrochimica acta · 2025Review
- Convolutional neural network for colorimetric glucose detection using a smartphone and novel multilayer polyvinyl film microfluidic device.Scientific reports · 2024Article
- Microfluidic Paper-Based Device Incorporated with Silica Nanoparticles for Iodide Quantification in Marine Source Dietary Supplements.Sensors (Basel, Switzerland) · 2024Article
- Printed Capillary Microfluidic Devices and Their Application in Biosensing.Micromachines · 2023Article
- Advancements in Preprocessing and Analysis of Nitrite and Nitrate since 2010 in Biological Samples: A Review.Molecules (Basel, Switzerland) · 2023Review
- Silica nanoparticle-modified paper strip-based new rhodamine B chemosensor for highly selective detection of copper ions in drinking water.Analytical and bioanalytical chemistry · 2023Article
- Application of Paper-Based Microfluidic Analytical Devices (µPAD) in Forensic and Clinical Toxicology: A Review.Biosensors · 2023Review
- Assessment of Bio-Based Materials as a Sustainable and Scalable Alternative for Detection of Plasmodium spp. (Haemospororida: Plasmodiidae) Sporozoites in Field Deployable Testing.Journal of medical entomology · 2023Article
- Paper-based analytical devices for point-of-need applications.Mikrochimica acta · 2023Review
- Enhanced Accumulation of Colloidal Particles in Microgrooved Channels via Diffusiophoresis and Steady-State Electrolyte Flows.Langmuir : the ACS journal of surfaces and colloids · 2022Article
- An Origami Paper-Based Biosensor for Allergen Detection by Chemiluminescence Immunoassay on Magnetic Microbeads.Biosensors · 2022Article
- Nanomaterial-assisted microfluidics for multiplex assays.Mikrochimica acta · 2022Review
- Colorimetric paper-based sarcosine assay with improved sensitivity.Analytical and bioanalytical chemistry · 2022Article
- Nano-functionalized paper-based IoT enabled devices for point-of-care testing: a review.Biomedical microdevices · 2021Review
- Enhanced passive mixing for paper microfluidics.RSC advances · 2021Article
- DNA-Gold Nanozyme-Modified Paper Device for Enhanced Colorimetric Detection of Mercury Ions.Biosensors · 2020Article
- Three-Dimensional Paper-Based Microfluidic Analysis Device for Simultaneous Detection of Multiple Biomarkers with a Smartphone.Biosensors · 2020Article
- Paper Stacks for Uniform Rehydration of Dried Reagents in Paper Microfluidic Devices.Scientific reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
This paper describes a silica nanoparticle-modified microfluidic paper-based analytical device (μPAD) with improved color intensity and uniformity for three different enzymatic reactions with clinical relevance (lactate, glucose, and glutamate). The μPADs were produced on a Whatman grade 1 filter paper and using a CO2 laser engraver. Silica nanoparticles modified with 3-aminopropyltriethoxysilane were then added to the paper devices to facilitate the adsorption of selected enzymes and prevent the washing away effect that creates color gradients in the colorimetric measurements. According to the results herein described, the addition of silica nanoparticles yielded significant improvements in color intensity and uniformity. The resulting μPADs allowed for the detection of the three analytes in clinically relevant concentration ranges with limits of detection (LODs) of 0.63 mM, 0.50 mM, and 0.25 mM for lactate, glucose, and glutamate, respectively. An example of an analytical application has been demonstrated for the semi-quantitative detection of all three analytes in artificial urine. The results demonstrate the potential of silica nanoparticles to avoid the washing away effect and improve the color uniformity and intensity in colorimetric bioassays performed on μPADs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.