ArticleThe Journal of antibiotics2015
Association of mutation patterns in GyrA and ParC genes with quinolone resistance levels in lactic acid bacteria.
Article in The Journal of antibiotics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Antibiotic-induced gut microbiome dysbiosis: risks and strategies for mitigation.The EMBO journal · 2026Review
- Molecular Epidemiology and Antibiotic Resistance of Sheep-DerivedAnimals : an open access journal from MDPI · 2025Article
- The diverse phenotypic and mutational landscape induced by fluoroquinolone treatment.mSystems · 2025Article
- Assessing the Antibiotic Resistance in Food Lactic Acid Bacteria: Risks in the Era of Widespread Probiotic Use.Food science & nutrition · 2025Review
- Antimicrobial activity of lactic acid bacteria isolated from the gut of African catfish (Clarias gariepinus) against multi-drug-resistant resident pathogens.BMC microbiology · 2025Article
- ProbioticCurrent research in food science · 2025Article
- Multidrug resistance profile in Lactobacillus delbrueckii: a food industry species with probiotic properties.World journal of microbiology & biotechnology · 2024Review
- Antibiotic resistance in potential probiotic lactic acid bacteria of fermented foods and human origin from Nigeria.BMC microbiology · 2023Article
- Assessing the drug resistance profiles of oral probiotic lozenges.Journal of oral microbiology · 2022Article
- Antibiotic Resistance Characterization of Bacteria Isolated from Traditional Chinese Paocai.Current microbiology · 2021Article
- Exploring Probiotic Activity of Lactobacillus sp. Isolated from Indigenous Breeds of Cattle Milk and Fecal Samples in Bhatan Village, MH., IN.Current microbiology · 2020Article
- Isolation and Comparative Genomic Analysis of Reuterin-ProducingFrontiers in microbiology · 2020Article
- Antibiotic Resistance of LACTOBACILLUS Strains.Current microbiology · 2019Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The quinolone resistance of 19 lactic acid bacterial strains belonging to the genera Enterococcus and Lactobacillus isolated from the natural fermented koumiss and yoghurt were investigated. The objective of this study was to determine the quinolone resistance levels and to explore the association of the resistance with the mutation patterns in gyrA and parC genes, as is currently recommended by the Food and Agriculture Organization/World Health Organization Joint Expert Committee in Guidelines for Evaluation of Probiotics in Food for probiotic lactic acid bacteria drug resistance in 2001. The Oxford Cup method and double-tube dilution method were used to determine the quinolone resistance levels of the isolated strains. Generally, all of the 19 strains showed resistance towards norfloxacin and ciprofloxacin when the Oxford cup method was used, whereas the incidence was lower (to norfloxacin 89.5% and to ciprofloxacin 68.4%) when minimum inhibitory concentration breakpoints (CLSI M100-S23) were tested. Furthermore, gene sequencing was conducted on gyrA and parC of topoisomerase II of these isolated strains. The genetic basis for quinolone resistance may be closely related to mutations in gyrA genes as there were 10 mutation sites in amino-acid sequences encoded by gyrA genes in 10 quinolone resistance strains and 14 mutation sites in Enterococcus durans HZ28, whereas no typical mutations were detected in parC genes.
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