ArticleJournal of natural products2014
Characterization of an orphan diterpenoid biosynthetic operon from Salinispora arenicola.
Article in Journal of natural products, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Favorable epistasis in ancestral diterpene synthases promoted convergent evolution of a resin acid precursor in conifers.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Discovery of bacterial terpenoids by genome mining.Methods in enzymology · 2025Article
- Traceability Research on GeographicMolecules (Basel, Switzerland) · 2024Article
- Actinomycetes as Producers of Biologically Active Terpenoids: Current Trends and Patents.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Structure-guided product determination of the bacterial type II diterpene synthase Tpn2.Communications chemistry · 2022Article
- Functional characterization and structural bases of two class I diterpene synthases in pimarane-type diterpene biosynthesis.Communications chemistry · 2021Article
- Trinorlabdane diterpenoid alkaloids featuring an unprecedented skeleton with anti-inflammatory and anti-viral activities fromRSC advances · 2021Article
- Bacterial terpenome.Natural product reports · 2021Review
- Combinatorial biosynthesis and the basis for substrate promiscuity in class I diterpene synthases.Metabolic engineering · 2019Article
- Identifying the Biosynthetic Gene Cluster for Triacsins with an N-Hydroxytriazene Moiety.Chembiochem : a European journal of chemical biology · 2019Article
- Discovery of the Tiancilactone Antibiotics by Genome Mining of Atypical Bacterial Type II Diterpene Synthases.Chembiochem : a European journal of chemical biology · 2018Article
- Comparative transcriptomics as a guide to natural product discovery and biosynthetic gene cluster functionality.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Genomic insights into specialized metabolism in the marine actinomycete Salinispora.Environmental microbiology · 2017Article
- Biosynthesis of the oxygenated diterpene nezukol in the medicinal plant Isodon rubescens is catalyzed by a pair of diterpene synthases.PloS one · 2017Article
- Extreme promiscuity of a bacterial and a plant diterpene synthase enables combinatorial biosynthesis.Metabolic engineering · 2016Article
- The marine actinomycete genus Salinispora: a model organism for secondary metabolite discovery.Natural product reports · 2015Review
- The application of synthetic biology to elucidation of plant mono-, sesqui-, and diterpenoid metabolism.Molecular plant · 2015Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
While more commonly associated with plants than microbes, diterpenoid natural products have been reported to have profound effects in marine microbe-microbe interactions. Intriguingly, the genome of the marine bacterium Salinispora arenicola CNS-205 contains a putative diterpenoid biosynthetic operon, terp1. Here recombinant expression studies are reported, indicating that this three-gene operon leads to the production of isopimara-8,15-dien-19-ol (4). Although 4 is not observed in pure cultures of S. arenicola, it is plausible that the terp1 operon is only expressed under certain physiologically relevant conditions such as in the presence of other marine organisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.