ArticleNature communications2014
Genome sequencing of chimpanzee malaria parasites reveals possible pathways of adaptation to human hosts.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.
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Who cites it
89 citing papers in PubMed, 134 citations in OpenAlex.
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- Plasmodium falciparum Glutamic Acid-Rich Protein-Independent Polyclonal Antibodies Inhibit Malaria Parasite Growth in Human Erythrocytes.The Journal of infectious diseases · 2024Article
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- Malaria Genomics, Vaccine Development, and Microbiome.Pathogens (Basel, Switzerland) · 2023Review
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- The role of upstream open reading frames in translation regulation in the apicomplexan parasitesParasitology · 2021Review
- Molecular Identification ofPathogens (Basel, Switzerland) · 2021Article
- Malaria in the 'Omics Era'.Genes · 2021Review
- Proteome size reduction in Apicomplexans is linked with loss of DNA repair and host redundant pathways.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2021Article
- Merozoite Proteins Discovered by qRT-PCR-Based Transcriptome Screening ofFrontiers in cellular and infection microbiology · 2021Article
- Calcium in the Backstage of Malaria Parasite Biology.Frontiers in cellular and infection microbiology · 2021Review
- Structure of theProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season.Nature medicine · 2020Article
- Ape Origins of Human Malaria.Annual review of microbiology · 2020Review
- Genomic and transcriptomic evidence for descent from Plasmodium and loss of blood schizogony in Hepatocystis parasites from naturally infected red colobus monkeys.PLoS pathogens · 2020Article
- Multiple Genomic Events Altering Hominin SIGLEC Biology and Innate Immunity Predated the Common Ancestor of Humans and Archaic Hominins.Genome biology and evolution · 2020Article
29 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors at 7 institutions in 5 countries.
Funding
Abstract
Plasmodium falciparum causes most human malaria deaths, having prehistorically evolved from parasites of African Great Apes. Here we explore the genomic basis of P. falciparum adaptation to human hosts by fully sequencing the genome of the closely related chimpanzee parasite species P. reichenowi, and obtaining partial sequence data from a more distantly related chimpanzee parasite (P. gaboni). The close relationship between P. reichenowi and P. falciparum is emphasized by almost complete conservation of genomic synteny, but against this strikingly conserved background we observe major differences at loci involved in erythrocyte invasion. The organization of most virulence-associated multigene families, including the hypervariable var genes, is broadly conserved, but P. falciparum has a smaller subset of rif and stevor genes whose products are expressed on the infected erythrocyte surface. Genome-wide analysis identifies other loci under recent positive selection, but a limited number of changes at the host-parasite interface may have mediated host switching.
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