Evidence map›Paper›PMID 25202697›Full record

ReviewHepatobiliary surgery and nutrition2014

Are hematopoietic stem cells involved in hepatocarcinogenesis?

Antonio Facciorusso, Matteo Antonino, Valentina Del Prete, Viviana Neve, Maria Principia Scavo, Michele Barone

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Hepatobiliary surgery and nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  11. Prognostic value ofOncoTargets and therapy · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Antonio Facciorusso1 Gastroenterology Unit, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy ; 2 Methodist Research Institute, Houston, USA.
Matteo Antonino1 Gastroenterology Unit, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy ; 2 Methodist Research Institute, Houston, USA.
Valentina Del Prete1 Gastroenterology Unit, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy ; 2 Methodist Research Institute, Houston, USA.
Viviana Neve1 Gastroenterology Unit, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy ; 2 Methodist Research Institute, Houston, USA.
Maria Principia Scavo1 Gastroenterology Unit, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy ; 2 Methodist Research Institute, Houston, USA.
Michele Barone1 Gastroenterology Unit, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy ; 2 Methodist Research Institute, Houston, USA.
University of Foggia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

the liver has three cell lineages able to proliferate after a hepatic injurythe mature hepatocyte, the ductular "bipolar" progenitor cell termed "oval cell" and the putative periductular stem cell. Hepatocytes can only produce other hepatocytes whereas ductular progenitor cells are considerate bipolar since they can give rise to biliary cells or hepatocytes. Periductular stem cells are rare in the liver, have a very long proliferation potential and may be multipotent, being this aspect still under investigation. They originate in the bone marrow since their progeny express genetic markers of donor hematopoietic cells after bone marrow transplantation. Since the liver is the hematopoietic organ of the fetus, it is possible that hematopoietic stem cells may reside in the liver of the adult. This assumption is proved by the finding that oval cells express hematopoietic markers like CD34, CD45, CD 109, Thy-1, c-kit, and others, which are also expressed by bone marrow-derived hematopoietic stem cells (BMSCs). Few and discordant studies have evaluated the role of BMSC in hepatocarcinogenesis so far and further studies in vitro and in vivo are warranted in order to definitively clarify such an issue.

Indexed as

carcinogenesishematopoieticHepatocellular carcinoma (HCC)stem cells

Identifiers

PMID25202697
PMCPMC4141297
OpenAlexW6595454

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.