ArticleJournal of reproduction & infertility2014
The effect of progesterone suppositories on threatened abortion: a randomized clinical trial.
Article in Journal of reproduction & infertility, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02601898 (Vaginal Administration of Alpha Lipoic Acid vs Progesterone for the Subchorionic Hematoma Treatment), which is not on this map. Cited by 17 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Vaginal Administration of Alpha Lipoic Acid vs Progesterone for the Subchorionic Hematoma Treatment
Who cites it
17 citing papers in PubMed, 5 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Progestogens in women with threatened miscarriage or recurrent miscarriage: A meta-analysis.Acta obstetricia et gynecologica Scandinavica · 2024Pooled it
- Pregnancy-related complications and perinatal outcomes following progesterone supplementation before 20 weeks of pregnancy in spontaneously achieved singleton pregnancies: a systematic review and meta-analysis.Reproductive biology and endocrinology : RB&E · 2021Pooled it
- Efficacy of progesterone on threatened miscarriage: an updated meta-analysis of randomized trials.Archives of gynecology and obstetrics · 2021Pooled it
- Progestogen for treating threatened miscarriage.The Cochrane database of systematic reviews · 2018Pooled it
- The Influence of Oral Dydrogesterone and Vaginal Progesterone on Threatened Abortion: A Systematic Review and Meta-Analysis.BioMed research international · 2017Pooled it
- Predicting the risk of threatened abortion using machine learning methods: a comparative study.BMC pregnancy and childbirth · 2025Article
- PERİDER-TJOD joint review on threatened abortion and guideline for its treatment.Turkish journal of obstetrics and gynecology · 2025Article
- Construction of machine learning tools to predict threatened miscarriage in the first trimester based on AEA, progesterone and β-hCG in China: a multicentre, observational, case-control study.BMC pregnancy and childbirth · 2022Observational
- Evaluation of per Vaginal Bleeding With Different Drugs in Successful Pregnancy in Patients With Recurrent Pregnancy Loss: An Original Research.Journal of pharmacy & bioallied sciences · 2022Article
- A Comparative, Randomized Control Trial in Patients of Per Vaginal Bleeding Comparing Efficacy of Oral Dydrogesterone Versus Vaginal Progesterone in Successful Pregnancy Outcome for Patients with Recurrent Pregnancy Loss.Journal of obstetrics and gynaecology of India · 2021Article
- Benefits of α-lipoic acid in high-risk pregnancies (Review).Experimental and therapeutic medicine · 2021Review
- Evaluation of Medicine Exposure During Pregnancy at a Tertiary Center of an Indian State.Maedica · 2020Article
- Evaluating the Effect of Utrogestan on Idiopathic Intrauterine Growth Retardation.Advanced biomedical research · 2020Article
- Efficacy and safety of oral nifedipine with or without vaginal progesterone in the management of threatened preterm labor.International journal of reproductive biomedicine · 2019Article
- The Role Of Progestogens In Threatened And Idiopathic Recurrent Miscarriage.International journal of women's health · 2019Review
- Risk factors of different congenital heart defects in Guangdong, China.Pediatric research · 2016Article
- Oral versus Vaginal Micronized Progesterone for the Treatment of Threatened Miscarriage.Pakistan journal of medical sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThreatened abortion is a common complication of pregnancy. In order to prevent miscarriage in the cases with threatened abortion, this study was conducted to determine whether progesterone suppository is effective in allowing pregnancy to proceed beyond week 20 in women with threatened abortion.
methodsThis single-blind clinical trial study was done on 60 pregnant women with threatened abortion. Pregnant women, who had vaginal bleeding until 20 weeks of their pregnancy, were assessed for inclusion. Participants were divided into two groups by random allocation; the control group, which did not undergo any treatment and the case group. The case group was given 400 mg of vaginal progesterone suppository (Cyclogest) each day until their bleeding stopped in less than one week. Participants were followed up until the end of their pregnancy. The treatment was considered successful if pregnancy continued beyond 20 weeks of gestation. Qualitative and quantitative variables were analyzed statistically by Chi Square and T- test respectively. The p-values of less than 0.05 were considered significant.
resultsThere was no statistically significant difference between the case and the control groups in terms of background variables. The number of abortions in the case group (6 cases, 20%) was lower than the control group which had 10 abortions (33.3%).
conclusionThe study demonstrated that the rate of abortion was reduced in women treated with progesterone suppositories. However, the difference was not statistically significant.
Indexed as
Identifiers
25202672PMC4138421W2117998761What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.